alexa Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera cereifera Seem
ISSN: 0974-8369

Biology and Medicine
Open Access

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Research Article

Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera cereifera Seem

strong>Md. Reyad-ul-Ferdous1,2,3*, Tamara Towshin Alam2, Md. Atiqul Islam3, Md. Zahirul Islam Khan3, Fariha Tasnim2, Md Eshak Khan3, Md Sharif Ullah3 and Tazmel Haque3

1Department of Pharmacy, Progati Medical Institute, Dhaka-1207, Bangladesh

2Department of Pharmacy, North South University, Dhaka-1229, Bangladesh

3Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh

*Corresponding Author:
Md. Reyad-ul-Ferdous
Lecturer, Department of Pharmacy
Progati Medical Institute, Dhaka-1207, Bangladesh
Tel: +880- 1719134213
E-mail: [email protected]

Received Date: September 22, 2014; Accepted Date: October 28, 2014; Published Date: November 04, 2014

Citation: Reyad-ul-Ferdous M, Alam TT, Islam MA, Khan MZI, Tasnim F, et al (2014) Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera cereifera Seem. Biol Med (Aligarh) 6:219. doi:10.4172/0974-8369.1000219

Copyright: © 2014 Reyad-ul-Ferdous M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In this present investigation, the fruits extract of Parmentiera cereifera were subjected to a comparative evaluation of the cardio-protective activities and Cytotoxic to brine shrimps (Artemia salina) as compared with standard streptokinase (SK) and Vincristine sulphate (VS). The crude methanolic (ME) extract, Hexane (HXSF) soluble fraction, carbon tetrachloride (CTCSF) soluble fraction, the Aqueous (AQSF) and chloroform (CSF) soluble fraction fruits of P. cereifera were subjected to these studies. In thrombolytic study, the fruits extract crude methanolic (ME) extract and Hexane (HXSF) soluble fraction were demonstrated mild to moderate (2.5 to 21.50%) thrombolytic activity in human blood specimen compared with standard streptokinase (SK) 66.77%. The fruits extracts were demonstrated (1.78 to 79.90) significant Cytotoxic to A. salina with LC50 values ranging from 6.07 to 7.83 µg/mL compared with standard Vincristine sulphate (VS, LC50 value 0.45 µg/mL).

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