alexa Fascinating Giardia Lamblia and Vexing Chronic Spontane
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Fascinating Giardia Lamblia and Vexing Chronic Spontaneous Urticaria: An Under-appreciated Association

Mujtaba Hasan Siddiqui1 and Iqbal Akhtar Khan2*

1Assistant Professor (Medicine), The University of Lahore Teaching Hospital, Defence Road, Lahore, Pakistan

2Independent Scholar, Lahore, Pakistan

*Corresponding Author:
Prof. Iqbal Akhtar Khan
Lahore, Pakistan
E-mail: [email protected]

Received date: September 24, 2016; Accepted date: October 07, 2016; Published date: October 17, 2016

Citation: Siddiqui MH, Khan IA (2016) Fascinating Giardia Lamblia and Vexing Chronic Spontaneous Urticaria: An Under-appreciated Association. J Allergy Ther 7:241. doi:10.4172/2155-6121.1000241

Copyright: © 2016 Siddiqui MH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Chronic Spontaneous Urticaria (CSU) has been found to have a negative impact on all aspects of patients’ lives - physical, mental, social and emotional. The ubiquitous and fascinating Giardia lamblia is primarily a gastrointestinal pathogen but it may present atypically (with or without gastroenterological manifestations). A link between Giardiasis and CSU was identified in the past. However, the possibility of this combination has been under-appreciated in clinical practice, even in developed world, resulting in inordinate delay in reaching correct diagnosis and instituting targeted pharmacotherapy. Such a situation adds to the miseries of the patients, both mental anguish and physical suffering. Objectives: -To determine the role of Giardia lamblia in the causation of CSU -To ratify the effects of eradication of Giardia lamblia on the course of CSU Methods: The present study was conducted on 63 referred cases of CSU (with insignificant improvement from the treatment already instituted). In view of the possibility of concomitant Giardial infection stool microscopy was advised and three fresh stool specimens, taken on alternate days, were collected from every case and examined for parasites. The two validated instruments employed for comparing Patient Related Outcome Measures (PROMs), before and after treatment, were UAS7 (Urticaria Activity Score of 7days) and CU-Q2oL (Chronic Urticaria Quality of Life Questionnaire). Results: Twenty two percent of those tested were found to have sole infection with Giardia lamblia. Secnidazole Sodium, as a single oral dose, resulted in complete parasitological and clinical cure in 93% of the cases. The results of the PROMs were compared and correlated with the clinical picture. Conclusion: The effects of eradication of Giardia lamblia on the course of the urticaria were excellent. Complete resolution of symptoms was seen in 93% of cases (and no recurrence in the follow up period of 16 weeks) with specific anti-giardial therapy alone proving that the causative agent was Giardia lamblia and that there was no role for any concomitant dermatological pathology. There is a dire need for meaningful cooperation between specialists of Dermatology and Tropical Medicine, in the management of otherwise unexplained urticaria.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version