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ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Research Article

Formulation and Evaluation of Phenytoin Sodium Sustained Release Matrix Tablet

Nimmathota Madhavi2*, Beeravelli Sudhakar1, P.V.Ravikanth1, Kodisana Mohon2 and Kolapalli Ramana Murthy1

1Brown’s College of Pharmacy, Ammapalem, Khammam-507305, Andhra Pradesh India

2A.U.College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, India

*Corresponding Author:
Nimmathota Madhavi
A.U. College of Pharmaceutical Sciences
Andhra University, Visakhapatnam
Andhra Pradesh, India
E-mail: [email protected]

Received Date: May 30, 2012; Accepted Date: October 27, 2012; Published Date: October 29, 2012

Citation: Madhavi N, Sudhakar B, Ravikanth PV, Mohon K, Ramana Murthy K (2012) Formulation and Evaluation of Phenytoin Sodium Sustained Release Matrix Tablet. J Bioequiv Availab 4: 128-133. doi: 10.4172/jbb.1000125

Copyright: © 2012 Madhavi N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Epilepsy is a very common disorder, characterized by seizures, which take various forms and result from episodic neuronal discharges, the form of the seizure depending on the part of the brain affected. There is no recognition cause, although it may develop after brain damage, such as trauma, infection or trauma, and other kinds of neurological diseases. Epilepsy is treated mainly with drugs, though brain surgery may be used for severe cases. Sodium channel blockers are generally used in the treatment of seizures, e.g.: phenytoin, carbamazepine, sodium valproate. The aim of this study is to develop sustained release matrix tablet of phenytoin sodium using eudragit- RL100, eudragit-RS100, HPMC-E15, ethyl cellulose (N-14), Chitosan and HPMC as release controlling factor and to evaluate drug release parameters as per various release kinetic models. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. Criteria for selecting the most appropriate model were based on linearity (coefficient of correlation). Based on “n” value (0.168) the drug release was follows Fickian diffusion. Also the drug release mechanism was best explained by Higuchi order (correlation value is 0.9063) by using this polymer.

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