alexa Genomic Loci Evaluation with Albuminuria in New-Onset Insulin Dependent Diabetic Patients
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

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Research Article

Genomic Loci Evaluation with Albuminuria in New-Onset Insulin Dependent Diabetic Patients

Anna Sleder1 , Jia Li2 , Andrea Cassidy-Bushrow3 , Sharon Cresci4 , Keoki Williams5 , Hani N Sabbah6 and David Lanfear7 *

1 Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA

2 Electrical and Computer Engineering Department, Oakland University, Rochester, Michigan, USA

3 Department of Public Health Sciences, Henry Ford Hospital Detroit, Michigan, USA

4 Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri, USA

5 Center for Health Services Research, Henry Ford Hospital, Detroit, Michigan, USA

6 Cardiovascular Research Laboratories Henry Ford Hospital, Detroit, Michigan, USA

7 Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan, USA

*Corresponding Author:
David Lanfear
Heart and Vascular Institute
Henry Ford Hospital, 2799 W. Grand Blvd
K14, Detroit MI, 48202, USA
Tel: (313)916-6375
Fax: (313)916-8799
E-mail: [email protected]

Received date: October 25, 2013; Accepted date: January 22, 2014; Published date: January 29, 2014

Citation: Sleder A, Cassidy-Bushrow A, Cresci S, Williams K, Sabbah HN, et al. (2014) Genomic Loci Evaluation with Albuminuria in New-Onset Insulin Dependent Diabetic Patients. J Pharmacogenomics Pharmacoproteomics 5:122. doi: 10.4172/2153-0645.1000122

Copyright: © 2014 Sleder A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Extensive data supports the genetic underpinnings of diabetes and recent studies implicate several genetic loci associated with renal insufficiency and albuminuria. Moreover, albuminuria in diabetic patients is an important risk marker for atherosclerotic disease as well as cardiomyopathy. The purpose of this study was to identify genetic determinants of albuminuria in a diabetic patient population at the time of insulin initiation.

Methods: Study population included type 2 diabetic subjects at the time of initiation of insulin in an observational cohort who donated saliva samples for DNA extraction. Urine albumin to creatinine ratio (UACR) and HbA1c levels at baseline were collected and analyzed for association with genotype (N=128).

Results: Although none of the SNPs met statistical significance after Bonferroni adjustment, two regions showed near-significant associations with UACR; one on chromosome 1 (p=8.66 E-07) and one on chromosome 12 (p=9.82 E-07).

Conclusions: In this small study of newly insulin-dependent diabetics we identified two genomic regions possibly associated with albuminuria. These loci are good candidates for further investigation into the moderators of cardiovascular disease in diabetics. Larger confirmatory studies are needed.

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