Genomic Loci Evaluation with Albuminuria in New-Onset Insulin Dependent Diabetic PatientsAnna Sleder1 , Jia Li2 , Andrea Cassidy-Bushrow3 , Sharon Cresci4 , Keoki Williams5 , Hani N Sabbah6 and David Lanfear7 *
- *Corresponding Author:
- David Lanfear
Heart and Vascular Institute
Henry Ford Hospital, 2799 W. Grand Blvd
K14, Detroit MI, 48202, USA
E-mail: [email protected]
Received date: October 25, 2013; Accepted date: January 22, 2014; Published date: January 29, 2014
Citation: Sleder A, Cassidy-Bushrow A, Cresci S, Williams K, Sabbah HN, et al. (2014) Genomic Loci Evaluation with Albuminuria in New-Onset Insulin Dependent Diabetic Patients. J Pharmacogenomics Pharmacoproteomics 5:122. doi: 10.4172/2153-0645.1000122
Copyright: © 2014 Sleder A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Extensive data supports the genetic underpinnings of diabetes and recent studies implicate several genetic loci associated with renal insufficiency and albuminuria. Moreover, albuminuria in diabetic patients is an important risk marker for atherosclerotic disease as well as cardiomyopathy. The purpose of this study was to identify genetic determinants of albuminuria in a diabetic patient population at the time of insulin initiation.
Methods: Study population included type 2 diabetic subjects at the time of initiation of insulin in an observational cohort who donated saliva samples for DNA extraction. Urine albumin to creatinine ratio (UACR) and HbA1c levels at baseline were collected and analyzed for association with genotype (N=128).
Results: Although none of the SNPs met statistical significance after Bonferroni adjustment, two regions showed near-significant associations with UACR; one on chromosome 1 (p=8.66 E-07) and one on chromosome 12 (p=9.82 E-07).
Conclusions: In this small study of newly insulin-dependent diabetics we identified two genomic regions possibly associated with albuminuria. These loci are good candidates for further investigation into the moderators of cardiovascular disease in diabetics. Larger confirmatory studies are needed.