Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis
- *Corresponding Author:
- Aga Syed Sameer
Department of Basic Medical Sciences, College of Medicine
King Saud Bin Abdulaziz University for Health Sciences, Jeddah, KSA
E-mail: [email protected]
Received date: February 19, 2017; Accepted date: March 10, 2017; Published date: March 15, 2017
Citation: Nissar S, Sameer AS, Rasool R, Chowdri NA, Rashid F (2017) Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis. J Carcinog Mutagen 8:287. doi: 10.4172/2157-2518.1000287
Copyright: © 2017 Nissar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Glutathione S-transferases (GSTs) are enzymes detoxifying a wide range of hazardous substances both of endogenous or exogenous origin, such as reactive oxygen species (ROS) or xenobiotics and environmental carcinogens; thereby imparting protection to DNA against oxidative damage. GST gene polymorphisms on the other hand, exert an effect on the functioning of enzymes encoded by these genes at both gene expression level and the activity of the protein. In this way it may influence the possibility of detoxification of carcinogens, and consequently, the level of DNA damage; thus it may have an effect on the risk of development of cancer. In this review we aim to understand the function of GSTs in the xenobiotic metabolism and their role in modulation of colorectal cancer (CRC).