alexa Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis

Saniya Nissar1,2,3, Aga Syed Sameer4*, Roohi Rasool2, Nissar A Chowdri5 and Fouzia Rashid3

1Department of Biochemistry, University of Kashmir, India

2Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, India

3Department of Clinical Biochemistry, University of Kashmir, India

4Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences. Jeddah, KSA

5Department of General Surgery, Sher-I-Kashmir Institute of Medical Sciences, India

*Corresponding Author:
Aga Syed Sameer
Department of Basic Medical Sciences, College of Medicine
King Saud Bin Abdulaziz University for Health Sciences, Jeddah, KSA
Tel: +966542035086
E-mail: [email protected]

Received date: February 19, 2017; Accepted date: March 10, 2017; Published date: March 15, 2017

Citation: Nissar S, Sameer AS, Rasool R, Chowdri NA, Rashid F (2017) Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis. J Carcinog Mutagen 8:287. doi: 10.4172/2157-2518.1000287

Copyright: © 2017 Nissar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Glutathione S-transferases (GSTs) are enzymes detoxifying a wide range of hazardous substances both of endogenous or exogenous origin, such as reactive oxygen species (ROS) or xenobiotics and environmental carcinogens; thereby imparting protection to DNA against oxidative damage. GST gene polymorphisms on the other hand, exert an effect on the functioning of enzymes encoded by these genes at both gene expression level and the activity of the protein. In this way it may influence the possibility of detoxification of carcinogens, and consequently, the level of DNA damage; thus it may have an effect on the risk of development of cancer. In this review we aim to understand the function of GSTs in the xenobiotic metabolism and their role in modulation of colorectal cancer (CRC).

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