G-Protein Coupled Receptors Dimerization: Diversity in Somatostatin Receptors SubtypesUjendra Kumar *
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
- *Corresponding Author:
- Ujendra Kumar
Professor, Faculty of Pharmaceutical Sciences
The University of British Columbia, Canada
Tel: (604) 827-3660
Fax: (604) 822-3035
E-mail: [email protected]
Received date: August 19, 2013; Accepted date: November 01, 2013; Published date: November 07, 2013
Citation: Kumar U (2013) G-Protein Coupled Receptors Dimerization: Diversity in Somatostatin Receptors Subtypes. J Pharmacogenomics Pharmacoproteomics 4:120. doi: 10.4172/2153-0645.1000120
Copyright: © 2013 Kumar U. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Five specific receptor subtypes namely somatostatin receptor 1-5 (SSTR1-5) that are differentially expressed in central and peripheral tissue in selective manner have different role in many human pathological conditions. SSTRs possess seven-transmembrane spanning domains and are linked to G-proteins; therefore, belong to the superfamily of G-protein coupled receptors (GPCRs). There is a preponderance of evidence suggesting the importance of GPCR dimerization in receptor-biogenesis, regulation and pharmacology. SSTR subtypes dimerization, with specific interest on the formation of heterodimers within the family or other related receptors, generates novel receptors with unique pharmacological, biochemical and enhanced signaling properties distinct from those of the native receptor existing as monomers or dimers. An understanding of the molecular mechanisms involve in SSTR dimerization could offer a rationale in future drug design. Importantly, gaining insights on the structure, function and signaling pathways of SSTR subtypes would represent a major advance in improving the treatment of various diseases such as neurodegenerative diseases and the tumors of various origins. In addition to discuss the significance of SSTR subtypes homo-and heterodimerization in particular, this review first describes the concept of GPCRs dimerization and the role of key membrane associated signaling proteins.