alexa Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data
ISSN: 2153-0602

Journal of Data Mining in Genomics & Proteomics
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Research Article

Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data

Lubke GH1,5*, Laurin C1, Walters R1, Eriksson N2, Hysi P3, Spector TD3, Montgomery GW4, Martin NG4, Medland SE4 and Boomsma DI5

1Department of Psychology, University of Notre Dame, Notre Dame, IN, USA

223 and Me, Inc., Mountain View, CA, USA

3Twin Research and Genetic Epidemiology, Genetic Epidemiologist, King’s College London, London, England

4Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

5Department of Biological Psychology, VU University Amsterdam, Amsterdam Netherlands

*Corresponding Author:
Lubke GH
Associate Professor, Department of Psychology
University of Notre Dame, USA
Tel: (574)631-8789
Fax: (574)631-8333
E-mail: [email protected]

Received Date: August 20, 2013; Accepted Date: October 16, 2013; Published Date: October 20, 2013

Citation: Lubke GH, Laurin C, Walters R, Eriksson N, Hysi P, et al. (2013) Gradient Boosting as a SNP Filter: an Evaluation Using Simulated and Hair Morphology Data. J Data Mining Genomics Proteomics 4:143.doi: 10.4172/2153-0602.1000143

Copyright: © 2013 Lubke GH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Typically, genome-wide association studies consist of regressing the phenotype on each SNP separately using an additive genetic model. Although statistical models for recessive, dominant, SNP-SNP, or SNP-environment interactions exist, the testing burden makes an evaluation of all possible effects impractical for genome-wide data. We advocate a two-step approach where the first step consists of a filter that is sensitive to different types of SNP main and interactions effects. The aim is to substantially reduce the number of SNPs such that more specific modeling becomes feasible in a second step. We provide an evaluation of a statistical learning method called “gradient boosting machine” (GBM) that can be used as a filter. GBM does not require an a priori specification of a genetic model, and permits inclusion of large numbers of covariates. GBM can therefore be used to explore multiple GxE interactions, which would not be feasible within the parametric framework used in GWAS. We show in a simulation that GBM performs well even under conditions favorable to the standard additive regression model commonly used in GWAS, and is sensitive to the detection of interaction effects even if one of the interacting variables has a zero main effect. The latter would not be detected in GWAS. Our evaluation is accompanied by an analysis of empirical data concerning hair morphology. We estimate the phenotypic variance explained by increasing numbers of highest ranked SNPs, and show that it is sufficient to select 10K-20K SNPs in the first step of a two-step approach.

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