alexa Histopathology and Wound Healing in Oxytetracycline Tre
ISSN: 2155-9546

Journal of Aquaculture Research & Development
Open Access

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Research Article

Histopathology and Wound Healing in Oxytetracycline Treated Oreochromis niloticus (L.) Against Aeromonas hydrophila Intramuscular Challenge

Julinta RB1*, Abraham TJ1, Anwesha Roy1, Jasmine Singha1, Gadadhar Dash1, NageshTS2 and Patil PK3

1Department of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata, West Bengal, India

2Department of Fisheries Resource Management, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata, West Bengal, India

3Central Institute of Brackishwater Aquaculture, Indian Council of Agricultural Research, Raja Annamalai Puram, Chennai, Tamil Nadu, India

*Corresponding Author:
R. Beryl Julinta
Department of Aquatic Animal Health
Faculty of Fishery Sciences
West Bengal University of Animal
and Fishery Sciences, Chakgaria
Kolkata-700094, West Bengal, India
Tel: +91 98832 87694
E-mail: [email protected]

Received Date: June 03, 2017 Accepted Date: June 28, 2017 Published Date: June 30, 2017

Citation: Julinta RB, Abraham TJ, Roy A, Singha J, Dash G, et al. (2017) Histopathology and Wound Healing in Oxytetracycline Treated Oreochromis niloticus (L.) Against Aeromonas hydrophila Intramuscular Challenge. J Aquac Res Development 8: 488. doi: 10.4172/2155-9546.1000488

Copyright: © 2017 Julinta RB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antibiotics are very important tools for the control of fish bacterial diseases. Yet, there are strict regulations controlling the use of antibiotics in aquaculture. This study assessed the efficacy oxytetracycline dihydrate (OTC) at a dose of 2 g, 4 g, 6 g and 8 g/100 pounds fish/day against Aeromonas hydrophila challenge in Nile tilapia Oreochromis niloticus as well as the histopathological alterations in kidney and muscle, and wound healing. The commercial pellet feed was top dressed with OTC using 5 ml vegetable oil as a binder. The fish were injected intramuscularly with A. hydrophila at ≈1 × 108 cells/fish and then fed OTC feeds at 2% of their body weight for 10 days. The fish fed with 8g OTC/100 pounds fish/day recorded the lowest mortality (3.33%). The untreated fish recorded 8.33% mortality. Histologically, the kidney tissues of O. niloticus exhibited nephropathy and glomerulopathy. The kidney of OTC fed groups had improved organization of nephritic tubules and glomerulus. The muscle tissues exhibited haemocyte infiltration with mild necrosis initially, followed by melanization and disrupted muscle bundles. The results demonstrated that the OTC treatment for 10 days could bring out improved functioning of fish kidneys that carry infectious agents. Within 3 days of OTC therapy, tissue reddening and inflammation subsided with the formation of black scar. Full recovery of normal skin architecture was reached within 26-31 days post-injection. Based on the results, prudent use of 4-8 g OTC/100 pounds fish/day is recommended for the control of A. hydrophila infection in O. niloticus.

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