alexa How Resident Stem Cells Communicate with Cardiac Cells
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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How Resident Stem Cells Communicate with Cardiac Cells in Beating Heart?

Vincenzo Lionetti1,2,3*

1Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy

2Fondazione CNR-Regione Toscana “G. Monasterio”, Pisa, Italy

3Unit of Translational Medicine, Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, Italy

*Corresponding Author:
Vincenzo Lionetti, MD, PhD
FAHA,Laboratory of Medical Science
Institute of Life Sciences,Scuola Superiore Sant’Anna
Piazza Martiri della Libertà, 3356124-Pisa, Italy
Tel: +39-050-3152216
Fax: +39-050-3152166
E-mail: [email protected]

Received date: November 03, 2011; Accepted date: November 04, 2011; Published date: November 06, 2011

Citation: Lionetti V (2011) How Resident Stem Cells Communicate with Cardiac Cells in Beating Heart? J Stem Cell Res Ther 1:e104. doi:10.4172/2157-7633.1000e104

Copyright: © 2011 Lionetti V. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The adult myocardium is a dynamic tissue with different functions which normally adapts to endless mechanical loads throughout life. The complexity and diversity of myocardial responses to different conditions imply the coexistence of different cell types within a hierarchically ordered architecture. Rare stem/progenitor cells have been detected interspersed within the interstitium and/or adherent to the wall of the capillaries forming the myocardial microcirculation. The origin of these cells is still debated. Multipotent and self-renewing cells resident into the heart survive to a mechanically and biochemically active environment without acquiring a cardiac phenotype. The persistence of an intense physical and biochemical stress do not affect the gene profyle of these cells in beating heart. Otherwise, differentiated cardiac cells continually release humoral factors preserving the fate of stem/progenitor cells. It is conceivable that undifferentiated cardiac cells have a different bio-mechanical response threshold compared to cells resident in other tissue. The codification of the language adopted by cardiac stem/progenitor cells to communicate with each other and other myocardial cells will help the cardiovascular therapy to fulfill its true potential.

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