alexa In vitro Inhibition of Staphylococcus aureus Isolates b
ISSN: 2157-7560

Journal of Vaccines & Vaccination
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Research Article

In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein (SpA)

Angel Alberto Justiz Vaillant1, Patrick Eberechi Akpaka1*, Monica Smikle2 and Norma McFarlane-Anderson3

1Departments of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, Trinidad and Tobago

2Department of Microbiology, Faculty of Medical Sciences, The University of the West Indies, Mona Campus, Kingston, Jamaica

3Department Basic Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, Mona Campus, Kingston, Jamaica

*Corresponding Author:
Dr. Patrick Eberechi Akpaka
Departments of Paraclinical Sciences
Faculty of Medical Sciences , The University of the West Indies
St. Augustine Campus, Trinidad and Tobago
Tel: +868-736-0440
Fax: +868-663- 3797
E-mail: [email protected]

Received Date: December 21, 2011; Accepted Date: March 05, 2012; Published Date: March 10, 2012

Citation: Justiz Vaillant AA, Akpaka PE, Smikle M, McFarlane-Anderson N (2012) In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein (SpA). J Vaccines Vaccin 3:127. doi: 10.4172/2157-7560.1000127

Copyright: © 2012 Justiz Vaillant AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

This study investigates the ability of antibodies to SpA (a protein produced by the bacterium Staphylococcus aureus) to inhibit the growth of the bacteria. Chickens immunised with SpA produced anti -SpA antibodies in their eggs (primarily the yolk). These anti-SpA antibodies were used to feed chicks, which produce antibodies that recognise the original antigen. When these antibodies were purified from their sera and included in the growth medium of the Staphylococcus aureus, there was inhibition of the bacterial growth. This indicates that these antibodies had specifically bound to the cell surface of the bacteria and prevented growth of the bacteria, i.e. the antibodies could protect against bacterial infection. The potential of such antibody in the hyper-immune egg to act as oral therapeutic agents is discussed.

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