In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein (SpA)
- *Corresponding Author:
- Dr. Patrick Eberechi Akpaka
Departments of Paraclinical Sciences
Faculty of Medical Sciences , The University of the West Indies
St. Augustine Campus, Trinidad and Tobago
Fax: +868-663- 3797
E-mail: [email protected]
Received Date: December 21, 2011; Accepted Date: March 05, 2012; Published Date: March 10, 2012
Citation: Justiz Vaillant AA, Akpaka PE, Smikle M, McFarlane-Anderson N (2012) In vitro Inhibition of Staphylococcus aureus Isolates by Anti-Anti-Idiotypic Antibodies to Staphylococcal Protein (SpA). J Vaccines Vaccin 3:127. doi: 10.4172/2157-7560.1000127
Copyright: © 2012 Justiz Vaillant AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This study investigates the ability of antibodies to SpA (a protein produced by the bacterium Staphylococcus aureus) to inhibit the growth of the bacteria. Chickens immunised with SpA produced anti -SpA antibodies in their eggs (primarily the yolk). These anti-SpA antibodies were used to feed chicks, which produce antibodies that recognise the original antigen. When these antibodies were purified from their sera and included in the growth medium of the Staphylococcus aureus, there was inhibition of the bacterial growth. This indicates that these antibodies had specifically bound to the cell surface of the bacteria and prevented growth of the bacteria, i.e. the antibodies could protect against bacterial infection. The potential of such antibody in the hyper-immune egg to act as oral therapeutic agents is discussed.