alexa Induction of Anti-inflammatory Cytokines in CD11b- and Gr-1- Positive Cells after Neuropathogenic Coronaviral Infection

Journal of Infectious Diseases and Diagnosis
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Research Article

Induction of Anti-inflammatory Cytokines in CD11b- and Gr-1- Positive Cells after Neuropathogenic Coronaviral Infection

Masatoshi Kakizaki1, Akira Togayachi2 and Rihito Watanabe1*

1Department of Bioinformatics, Graduate School of Engineering, Soka University, Tangi-cho, Hachioji, Tokyo, Japan

2Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Central-2, 1-1-1 Umezono, Tsukuba, Ibaraki, Japan

*Corresponding Author:
Rihito Watanabe
Department of Bioinformatics, Graduate School of Engineering
Soka University, Tangi-cho, Hachioji, Tokyo, Japan
Tel: +81-426-9465
E-mail: [email protected]

Received date: March 21, 2017; Accepted date: April 06, 2017; Published date: April 06, 2017

Citation: Kakizaki M, Togayachi A, Watanabe R (2017) Induction of Anti-inflammatory Cytokines in CD11b- and Gr-1- Positive Cells after Neuropathogenic Coronaviral Infection. J Infect Dis Diagn 2:112.

Copyright: © 2017 Kakizaki M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Mu-3 virus (Mu-3), a neuropathogenic strain of the mouse hepatitis virus, induces the apoptosis of pyramidal neurons in CA2 and CA3 subregions of the hippocampus at 4 days post-inoculation (dpi), without showing destructive changes or viral invasion there at 3 dpi. Since it has been considered that the apoptotic lesions occur through the indirect effects of infection, local expression of cytokines was examined in the brain in our previous study, revealing that the anti-inflammatory cytokine IL-10 is produced by pyramidal neurons of CA2 and CA3 after infection. However, infection of primary brain culture failed to elevate IL-10 production. Therefore, in order to examine whether Mu-3 infection elevates IL-10 production, CD11b-expressing Peritoneal Exudate Cells (PECs) were used, which showed an increased level of IL-10 production in the supernatant of PEC culture after infection. The finding that IL-10-producing cells expressed Lewis X (Lex) supports our previous hypothesis that Lex expression is involved in the immunosuppressive state induced by viral infection. In addition, in combination with an experiment involving ex vivo infection, it was indicated that Mu-3 elicits M2 macrophages or Gr-1+CD11b+ Myeloid- Derived Suppressor Cells (MDSCs) that produce IL-10 and TGF-β to circumvent the host immune response after infection.

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