alexa Inhibitory Effects and Anti-Invasive Activities of Treh
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Research Article

Inhibitory Effects and Anti-Invasive Activities of Trehalose Liposomes on the Proliferation of Lung Carcinoma Cells

Keiji Kuwabara, Hideaki Ichihara and Yoko Matsumoto*

Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan

*Corresponding Author:
Yoko Matsumoto
Division of Applied Life Science
Graduate School of Engineering, Sojo University
4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan
Tel: +81 96 326 3965
Fax: +81 96 323 1331
E-mail: [email protected]

Received Date: January 16, 2017; Accepted Date: January 20, 2017; Published Date: January 25, 2017

Citation: Kuwabara K, Ichihara H, Matsumoto Y (2017) Inhibitory Effects and Anti-Invasive Activities of Trehalose Liposomes on the Proliferation of Lung Carcinoma Cells. J Carcinog Mutagen 8:283. doi: 10.4172/2157-2518.1000283

Copyright: © 2017 Kuwabara K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Inhibitory effects and anti-invasive activities of trehalose liposomes (DMTreC14) composed of L-α-dimyristoylphosphatidylcholine and α-D-glycopyranosyl-α-D-glucopiranoside monomyristate (TreC14) on the proliferation of human non-small cell lung carcinoma (A549) cells were examined in vitro. DMTreC14 with a hydrodynamic diameter less than 100 nm, were preserved for 4 weeks. The inhibitory effects of DMTreC14 on the proliferation of A549 cells accompanied with apoptosis were obtained. Enhancement of the accumulation of DMTreC14 into A549 membranes was observed. An increase in cellular membrane fluidity of A549 cell treated with DMTreC14 was observed on the basis of fluorescence depolarization method. DMTreC14 caused apoptosis for A549 cells through the activation of caspases and mitochondrial pathway. The anti-migration effects of DMTreC14 for A549 cells were observed through the inhibition of filopodia formation. The anti-invasion effects with the reduction of MMP-14 of DMTreC14 for A549 cells were obtained.


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