Iron Oxide Nanoparticle Improve the Antibacterial Activity of Erythromycin
Marlen Aparicio Caamaño, Mariana Carrillo-Morales and José de Jesús Olivares-Trejo*
Graduate Genomic Sciences, Autonomous University of Mexico City, Mexico
- *Corresponding Author:
- José de Jesús Olivares-Trejo
Posgrado en Ciencias Genómicas
Universidad Autónoma de la Ciudad de México
San Lorenzo 290, C.P. 03100, Ciudad de México
Tel: +525554886661 ext 15309
E-mail: [email protected]
Received date: January 22, 2016; Accepted date: March 21, 2016; Published date: March 24, 2016
Citation: Aparicio-Caamaño M, Carrillo-Morales M, Olivares-Trejo JJ (2016) Iron Oxide Nanoparticle Improves the Antibacterial Activity of Erythromycin. J Bacteriol Parasitol 7:267. doi: 10.4172/2155-9597.1000267
Copyright: © 2016 Aparicio-Caamaño M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Antimicrobial resistance is considered a public health problem around the world. Every day new resistance mechanisms emerge and spread globally. Therefore, is imperative to improve the treatment schemes that have been developed to cure infections caused by human pathogens for instance, Streptococcus pneumoniae. Here, we are proposing a strategy that consists on combine the drug with iron oxide nanoparticles (FeNPs). We synthetized FeNPs by chemical technique and they were functionalized in order to make them soluble and biologically compatible. The antimicrobial agent (erythromycin) was coupled to FeNPs and their antibacterial properties were analysed in bacterial cultures of S. pneumoniae. The antibacterial effect was improved when the drug was coupled to FeNPs, also, the bacterial viability was diminished in presence of FeNPs. Additionally, the capsule of the bacterium has an important role in the antibacterial effect, because a mutant without capsule (R6) was more sensible to antibacterial agent than a strain with capsule (TIGR4 or ATCC strain). Maybe the FeNPs help to erythromycin to cross the capsule. In conclusion the presence of FeNPs improve the antibacterial activity of erythromycin.