alexa Kinetic Spectrophotometric Determination of Betahistine Dihydrochloride and Etilefrine Hydrochloride in Pharmaceutical Formulation
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Kinetic Spectrophotometric Determination of Betahistine Dihydrochloride and Etilefrine Hydrochloride in Pharmaceutical Formulation

Sara M. Anis*, Mervat M. Hosny, Hisham E. Abdellatef, Mohamed N. El-Balkiny

Faculty of Pharmacy, Department of Analytical Chemistry, Zagazig University Zagazig, Egypt - postal code: 44519

*Corresponding Author:
Dr. Sara M. Anis
Faculty of Pharmacy, Department of Analytical Chemistry
Zagazig University Zagazig, Egypt - postal code: 44519
Tel: +201 073 076 04
Fax: +20 55 2303266
E-mail: [email protected]

Received date: November 22, 2010; Accepted date: December 15, 2010; Published date:February 25, 2011

Citation: Anis SM, Hosny MM, Abdellatef HE, El-Balkiny MN (2011) Kinetic Spectrophotometric Determination of Betahistine Dihydrochloride and Etilefrine Hydrochloride in Pharmaceutical Formulation. Pharm Anal Acta 2:116. doi: 10.4172/2153-2435.1000116

Copyright: © 2011 Anis SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The importance of betahistine dihydrochloride as an anti-vertigo medicine and of etilefrine hydrochloride in the management of hypotension necessitates the development of a simple, sensitive and inexpensive technique for their analysis. This study reports the development of an accurate, feasible kinetic technique for their determination. It is based on the reaction of the cited drugs with 4-chloro-7-nitrobenzofurazan (NBD–Cl) in presence of 0.05 M disodium hydrogen phosphate. The absorbance was measured at 496, and 503 nm for betahistine dihydrochloride and etilefrine hydrochloride respectively, at a fixed time of 30 minutes on thermostated water bath at 90°C. The absorbance concentration plots were rectilinear over the range 0.25–7 and 3–13 μg/ml for betahistine dihydrochloride and etilefrine hydrochloride, respectively. The method has been applied successfully to commercial tablet dosage form and can be further applied for their determination on a large scale in quality control laboratories, or in small laboratories. The obtained results statistically agreed with those obtained by official titrimetric methods. The determination of the studied drugs by the fixed concentration and rate constant methods is feasible with the calibration equations obtained, but the fixed time method proves to be more applicable.

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