alexa Long-Term In Vitro Effectiveness of A Bioglass Desensitizing Agent Investigated Using Electrochemical Impedance Spectroscopy, Atomic Force Microscopy and Scanning Electron Microscopy
ISSN: 2161-1122

Dentistry
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Research Article

Long-Term In Vitro Effectiveness of A Bioglass Desensitizing Agent Investigated Using Electrochemical Impedance Spectroscopy, Atomic Force Microscopy and Scanning Electron Microscopy

Shuya Shi1, Q Wu2, YT Xu3 and Yaming Chen4*

1Department of Stomatology, Affiliated Hospital of Jiangnan University, China

2Department of Polyclinic, Affiliated hospital of Stomatology, Nanjing Medical University, Nanjing, China

3Department of Endodontics, Suzhou Stomatological Hospital, China,

4Institute of Stomatology, Nanjing Medical University, Nanjing, China

*Corresponding Author:
Yaming Chen
Department of Prosthetic Dentistry
Institute of Stomatology
Nanjing Medical University
136 Hanzhong Road
Nanjing 210009, China
Tel: +862585031832
Fax: +862586516414
E-mail: [email protected]

Received date: February 21, 2017; Accepted date: March 20, 2017; Published date: April 03, 2017

Citation: Shi S, Wu Q, Xu YT, Chen YM (2017) Long-Term In Vitro Effectiveness of A Bioglass Desensitizing Agent Investigated Using Electrochemical Impedance Spectroscopy, Atomic Force Microscopy and Scanning Electron Microscopy. Dentistry 7:422. doi: 10.4172/2161-1122.1000422

Copyright: © 2017 Shi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: To compare the long-term in vitro effectiveness of a newer desensitizing agent containing bioactive glass and two other commercial products employed for dentin hypersensitivity.
Methods: Fifty occlusal dentin disks from extracted sound human third molars were treated with 0.5M ethylenediaminetetraacetic acid for 2 min then randomly divided into five groups (n=10). Specimens were brushed for 2 min twice daily with Actimins Paste (Group1), Lesening Super Desensitizing Toothpaste (Group2), Colgate Sensitive Pro-Relief Desensitising Polishing Paste (Group3) and distilled water (Group4) at 9:00 am and at 5:00 pm. Specimens in Group5 had no brushings. All specimens were immersed sequentially for 5 min into coffee (pH=5.4) at 10:00 am and undiluted cola (pH=2.5) at 6:00 pm. Dentin permeability was measured weekly over one month using electrochemical impedance spectroscopy (EIS). Data were analyzed using two-way repeated measures ANOVA and post hoc LSD tests. Dentin microstructures were observed at one month by atomic force microscopy and scanning electron microscopy.
Results: The three desensitizing agents significantly reduced dentin permeability over one month. Post hoc LSD tests of the EIS values indicated that brushing with Actimins showed no significant difference from Colgate Sensitive (P=0.32), and that both agents had significantly less permeability than Lesening (P<0.05). Conclusions: The three desensitizing agents were effective in occluding dentinal tubules and reducing permeability to varying extents over one month, with Actimins and Colgate Sensitive being the most effective. Actimins might be initially, a faster-working desensitizing agent.
Clinical significance: Actimins, a newer desensitizing agent containing bioactive glass, has the potential to relieve dentin hypersensitivity in the presence of long-term daily acidic beverage ingestion.

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