alexa Long-Term Results of Cultured Autologous Oral Mucosa Epithelial Cell-Sheet (CAOMECS) Graft for the Treatment of Blindness Due to Bilateral Limbal Stem Cell Deficiency
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Long-Term Results of Cultured Autologous Oral Mucosa Epithelial Cell-Sheet (CAOMECS) Graft for the Treatment of Blindness Due to Bilateral Limbal Stem Cell Deficiency

Kocaba V1*, Thépot A2, Yamato M5, Daisuke M5, Kellal M2, Mojallal A1, Damour O3,4 and Burillon C1

1Hospices Civils de Lyon, Hôpital Edouard Herriot, service d’Ophtalmologie, F-69003, Lyon, France

2Cell Seed France, Hôspital Edouard Herriot, Banque de tissus et cellules, F-69003, Lyon, France

3Hospices Civils de Lyon, Hôpital Edouard Herriot, Banque de tissus et cellules, F-69003, France

4Institut de Biologie et Chimie des Protéines, CNRS/Université de Lyon UMR5086, Lyon, France

5Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Japan

Corresponding Author:
Kocaba Viridiana
Hôspital Edouard Herriot
Pavillon C, Ophtalmologie, 5
place d’Arsonval, 69003 Lyon, France
Tel: +33 6 18 18 54 39; +33 4 72 11 62 11
E-mail: [email protected]

Received Date: February 21, 2014; Accepted Date: March 19, 2014; Published Date: March 21, 2014

Citation: Kocaba V, Thépot A, Yamato M, Daisuke M, Kellal M, et al. (2014) Long-Term Results of Cultured Autologous Oral Mucosa Epithelial Cell-Sheet (CAOMECS) Graft for the Treatment of Blindness Due to Bilateral Limbal Stem Cell Deficiency. J Stem Cell Res Ther 4:181. doi:10.4172/2157-7633.1000181

Copyright: © 2014 Kocaba V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Purpose: To treat bilateral corneal blindness due to limbal stem cell deficiency (LSCD) thanks to corneal transplant of an autologous epithelium of stem cells cultivated by the oral mucous membrane by the technology UpCell®-Insert (CAOMECS for Cultured Autologous Oral Mucosal Epithelial Cell-Sheet). Methods: The efficacy of a CAOMECS corneal graft was assessed over the long term for 23 out of 26 eyes presenting severe bilateral LSCD. This study follows a clinical trial evaluated, which lasted for 12 months. The major evaluation criterion was visual acuity and the minor criteria were the condition of the epithelium (a composite criterion assessed by grading superficial punctate keratitis, the presence of ulcer, the number and activity of neovessels and the presence of conjunctivalization) and the quality of life (grading of photophobia, dryness and pain). The mean follow-up was of 28 months [18-48 months]. Findings: Visual acuity was increased for 17 patients out of 23 treated (74%), the state of the epithelium was improved for 15 patients (62.5%) and the quality of life was improved for 22 patients (95.6%). For the nine patients with stromal opacity, CAOMECS grafting, reducing limbal neovascularization also made it possible to perform a penetrating keratoplasty (until then impossible because of insufficient stem cells causing acute graft rejection). In this group, visual acuity was increased in 66.7% of the cases; the state of the epithelium was improved in 66.7% and the quality of life in 100%. Interpretation: These long-term results demonstrate that CAOMECS contains the stem cells necessary for the constant renewal of the epithelium and restores the epithelial function of the cornea by delaying neovascularization and conjunctivalization. For patients with healthy stroma, an increase in visual acuity is possible with no other treatment. For those whose stroma is severely deteriorated, penetrating keratoplasty is then possible and improved visual acuity can be achieved. This study demonstrates that CAOMECS graft appears as an innovative and safe treatment for blindness due to LSCD.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version