MAGI Scaffolding Molecules Involved in Cancer Cell Signaling
Satoru Matsuda* and Yasuko Kitagishi
Department of Food Science and Nutrition, Nara Women’s University, Japan
- *Corresponding Author:
- Satoru Matsuda
Department of Food Science and Nutrition
Nara Women’s University
Kita-Uoya Nishimachi, Nara 630-8506, Japan
E-mail: [email protected]
Received date: May 28, 2013; Accepted date: July 29, 2013; Published date: August 05, 2013
Citation: Matsuda S, Kitagishi Y (2013) MAGI Scaffolding Molecules Involved in Cancer Cell Signaling. J Carcinogene Mutagene S7:005. doi: 10.4172/2157-2518.S7-005
Copyright: © 2013 Matsuda S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PTEN is a tumor suppressor gene inactivated in various human cancers, which antagonizes PI3K activity. The PI3K/AKT pathway is frequently activated in cancer, then, the PTEN tumor suppressor may be the major brake of the pathway. Cells that lack functional PTEN gene have constitutively higher levels of PIP3 and activated downstream targets. The PTEN protein binds to the MAGI proteins (MAGIs), which are scaffolding molecules with PDZ domain involved in the regulation of epithelial cell tight-junction assembly. Studies have revealed the potential relevance of the PDZ interactions to cancer cell behaviors. The molecular mechanisms contributing to cancer invasion are the subject of considerable investigation, as a better understanding of the pathogenesis will lead to the development of novel targeted therapies. We review recent studies on the features of PTEN and MAGIs in the signaling pathways involved in cancer progression.