alexa Malaria in HIV/AIDS Patients at Different CD4+ T Cell L
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

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Research Article

Malaria in HIV/AIDS Patients at Different CD4+ T Cell Levels in Limbe, Cameroon

Helen K Kimbi1*, Doris T Njoh1, Kenneth JN Ndamukong2, and Leopold G Lehman2

1Department of Zoology and Animal Physiology, University of Buea, P.O. Box 63, Buea, SWR, Cameroon

2Department of Animal Biology, University of Douala, P.O. Box 2701, Douala, Cameroon

*Corresponding Author:
Helen Kuokuo Kimbi
Department of Zoology and Animal Physiology
University of Buea, P.O. Box 63
Buea, SWR, Cameroon
Tel: +2377783 66 03/9403 53 55
Fax: +237 3332 22 72
E-mail: [email protected]

Received date: December 06, 2012; Accepted date: December 29, 2012; Published date: January 03, 2013

Citation: Kimbi HK, Njoh DT, Ndamukong KJN, Lehman LG (2013) Malaria in HIV/AIDS Patients at Different CD4+ T Cell Levels in Limbe, Cameroon. J Bacteriol Parasitol 4:164. doi: 10.4172/2155-9597.1000164

Copyright: © 2013 Kimbi HK et al, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

HIV infection has resulted in an increased risk of severe malaria and death, because the odds of parasitaemia and risk of malaria fever increase with decreasing CD4+ T cell count and increasing viral load. A cross-sectional study was conducted on 203 HIV/AIDS patients to determine the pattern of malaria infection, anaemic status and the outcome of ARV therapy vis-à-vis malaria treatment at different CD4+ T cell levels of the patient. Participants were HIV patients aged ≥ 20 years attending the HIV treatment centre of Limbe Regional Hospital, Cameroon. Clinical manifestations of malaria in patients were determined using a structured questionnaire. Their CD4+ T cell count and haemoglobin level were determined using the FACS count method. Malaria prevalence and density were determined from Giemsa-stained blood films. Clinical manifestations of malaria increased with decreasing CD4+ T cell counts. There was a negative correlation between malaria severity and decreasing CD4+ T cell counts. A significantly greater proportion (p<0.01) of patients had moderate anaemia. Cases of anaemia increased significantly (p<0.001) with decreasing CD4+ T cell counts. Declining immunity increases vulnerability to malaria infection and highly active ARV combination therapy has great potential to reduce HIV-related malaria.

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