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ISSN: 2155-9597

Journal of Bacteriology & Parasitology
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Research Article

Malignant Ovine Theileriosis: Alterations in the Levels of Homocysteine, Thyroid Hormones and Serum Trace Elements

S. Nazifi1*, S. M. Razavi2, N. Safi1 and E. Rakhshandehroo2

1Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

*Corresponding Author:
S. Nazifi
Department of Clinical Studies
School of Veterinary Medicine, Shiraz University
Shiraz, P.O. Box: 1731-71345, Iran
Tel: +98-711-2286940
Fax: +98-711-2286950
E-mail: [email protected]

Received date: August 21, 2012; Accepted date: September 17, 2012; Published date: September 20, 2012

Citation: Nazifi S, Razavi SM, Safi N, Rakhshandehroo E (2012) Malignant Ovine Theileriosis: Alterations in the Levels of Homocysteine, Thyroid Hormones and Serum Trace Elements. J Bacteriol Parasitol 3:150. doi: 10.4172/2155-9597.1000150

Copyright: ©2012 Nazifi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Malignant ovine theileriosis is a fatal disease of sheep caused by the pathogenic species of protozoans of the genus Theileria. This study was designed to estimate the levels of plasma homocysteine (Hcy), serum thyroid hormones, the serum trace elements and to evaluate their correlations in different parasitemia rates in naturally Theileria infected sheep.
Materials and Methods: 50 Iranian sheep, about 1-2 years old, naturally infected with T. lestoquardi were selected and divided into 2 subgroups according to parasitemia rates (<2%, 2-4%). 10 non-infected animals were also selected as controls. Blood samples were collected and Hcy, thyroid hormones and major trace elements were measured.
Results: Significant decrease in the values of red blood cell count (RBC), packed cell volume (PCV) and hemoglobin confirmed that anaemia had occurred in the infected sheep. Significant increase in Hcy and some trace elements (Mn, Fe and Zn), significant decrease in the values of thyroxine (T4) and free tri-iodothyronine (fT3) were observed.
Conclusion: Substantial elevations in plasma Hcy can potentially produce endothelial injuries and consequently help the formation of anaemia. On the other hand, significant decrease in T4 and fT3 and increase in some trace elements (Mn, Fe and Zn) besides the lack of any changes in the other related factors, indicate that the infection of sheep with lower than 4% parasitemia rates, can induce negative effects on the secretion and concentrations of thyroid hormones, but the infection could not cause reverse effects on important trace elements.

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