Management of Blood Transfusion in a Patient Carring Anti-Rh18 Associated with the RHD*Weak D 4.2.2/RHCE*ceAR Haplotype
- *Corresponding Author:
- José O. Bordin, MD
Disciplina de Hematologia e Hemoterapia
Universidade Federal de São Paulo, Brazil
Tel: 55 11 55791550
E-mail: [email protected]
Received date: July 04, 2015 Accepted date: July 27, 2015 Published date: July 31, 2015
Citation: Costa SSM, Chiba AK, Cruz BR, Fabron Jr A, Chiattone CS, et al. (2015) Management of Blood Transfusion in a Patient Carring Anti-Rh18 Associated with the RHD*Weak D 4.2.2/RHCE*ceAR Haplotype. J Blood Disord Transfus S4:004. doi: 10.4172/2155-9864.1000S4-004
Copyright: © 2015 Costa SSM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The RH blood group system is the most polymorphic and immunogenic among blood groups. Variant Rh antigens have been found with high frequencies in African descendants persons. The DAR-ceAR haplotype results from the rearrangement of the RHCE gene with the internal sequences of the RHD gene that give rise to an altered Rh protein and may produce a clinically significant antibody. We report a case of anti-RH18 detected in a female patient with sickle cell trait. Serologic and molecular investigations were performed to identify RH variants from the propositus and her relatives. The results of genomic DNA analysis showed the propositus carrying the haplotype RHD*weak D 4.2.2/RHCE*ceAR, as well as her father and sister.