Microfluidic Platforms for Gradient Generation and its ApplicationsChunfei Hu, Jingjing Liu, Hongmei Chen and Fuqiang Nie*
Division of Nanobionic Research, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, P.R. China
- *Corresponding Author:
- Fuqiang Nie
Division of Nanobionic Research
Suzhou Institute of Nano-Tech and Nano-Bionics
Chinese Academy of Sciences
398 Ruoshui Road, Suzhou, 215123, P.R. China
E-mail: [email protected]
Received Date: April 11, 2017; Accepted Date: June 01, 2017; Published Date: June 05, 2017
Citation: Hu C, Liu J, Chen H, Nie F (2017) Microfluidic Platforms for Gradient Generation and its Applications. Biochem Anal Biochem 6: 320. doi: 10.4172/2161-1009.1000320
Copyright: © 2017 Hu C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Due to criticality of gradients in both chemical and biological fields, generating stable and controllable gradient concentration in microfluidics has significance such as analysis of cell migration, cancer metastasis, drug screening, chemotaxis and chemical synthesis. Integrated microfluidic chips are particularly amenable to gradient generation. Microfluidic chips functioning as concentration gradient have made great progress based on various principles. Diverse advanced microfluidic platforms have been developed as convection mixing-based gradient generators, laminar flow diffusion-based gradient generators, static diffusion-based gradient generator and geometric metering mixing-based gradient generator. In this review, we discuss recent advances and wide application of microfluidic gradient generators.