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Abstract
Mini Review: Pharmacotherapy for Behavioral and Psychological Symptoms in Alzheimer's Disease
Koji Hori, Kimiko Konishi, Hiroaki Tanaka, Sachiko Yokoyama, Mari Aoki, Kazunari Azuma, Koichi Zinbo, Masaki Okada and Mitsugu Hachisu
Object: To show the clinical implications for pharmacotherapy for Behavioral and Psychological Symptoms of Dementia (BPSD) in Alzheimer?s Disease (AD). Background: In Japan, no medicine is permitted for BPSD in AD. On the contrary, atypical antipsychotics are inhibited because mortality rate increases when these medicines are prescribed for elderly demented patients. Methods and results: We reviewed our previous articles those reported the effects of aging and disease progress on BPSD and showed that effects of aging and disease progress caused the connections of the mood cluster (anxieties and affective disturbances) with the psychiatric cluster (delusions and hallucinations) and aggressiveness. Conclusion: BPSD in AD was similar with bipolar features of mixed type or psychotic depression. We might prescribe medications for augmentation of depression to BPSD in AD.