alexa Molecular Characterization and Expression Pattern of a Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) Gene in Yellow Catfish (Pelteobagrus fulvidraco) | Abstract
ISSN: 2155-9546

Journal of Aquaculture Research & Development
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Research Article

Molecular Characterization and Expression Pattern of a Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) Gene in Yellow Catfish (Pelteobagrus fulvidraco)

Gang Ren1,2, Wen-Ying Shen1*, Wei-Fen Li2 and Yao-rong Zhu1

1Department of Biology, College of Life Science, Shaoxing University, Shaoxing 312000, China

2College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

*Corresponding Author:
Wen-Ying Shen
Department of Biology, College of Life Science
Shaoxing University, Zhejiang province
312000, People’s Republic of China
Tel: +86 575 88345863
Fax: +86 575 88345012
E-mail: [email protected]

Received Date: March 18, 2014; Accepted Date: April 23, 2014; Published Date: April 30, 2014

Citation: Ren G, Shen WY, Li WF, Zhu YR (2014) Molecular Characterization and Expression Pattern of a Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) Gene in Yellow Catfish (Pelteobagrus fulvidraco). J Aquac Res Development 5:229. doi:10.4172/2155-9546.1000229

Copyright: © 2014 Ren G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Liver-expressed antimicrobial peptide 2 (LEAP-2) is a member of antimicrobial peptides, which acts as an
important component of the host innate immune system and plays a crucial role in host defense against microbial invasion. In this study, a LEAP-2 gene (PfLEAP-2) was amplified from the liver of yellow catfish (Pelteobagrus fulvidraco) by reverse transcription PCR. The length of P LEAP-2 open reading frame was 282 bp, which encode 94 amino acids (aa) including a 28-aa signal peptide, a 21-aa prodomain, and a 45-aa mature peptide. The results of tissue distribution showed that PfLEAP-2 mRNA was mainly expressed in the gill, skin, stomach, and head kidney. The significant up-regulation of PfLEAP-2 in liver after 4 hours of challenge of Edwardsiella tarda suggested, PfLEAP-2 might play an important role in the early immune defense of the yellow catfish against bacterial pathogen

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