alexa Molecular Docking Studies of PA-824 with Pyridoxine 5'-Phosphate Oxidase | OMICS International | Abstract
ISSN: 0974-8369

Biology and Medicine
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Research Article

Molecular Docking Studies of PA-824 with Pyridoxine 5'-Phosphate Oxidase

Sathish Kumar M1* and Jaleel UCA2

1CSIR OSDD Research Unit, Bangalore, India

2Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

*Corresponding Author:
Sathish Kumar M
CSIR OSDD Research Unit
Bangalore, India
Tel: 0431 240 7072
E-mail: [email protected]

Received date: December 02, 2015; Accepted date: January 28, 2016; Published date: February 01, 2016

Citation: Kumar MS, Jaleel UCA (2016) Molecular Docking Studies of PA-824 with Pyridoxine 5'-Phosphate Oxidase. Biol Med (Aligarh) 8:274. doi:10.4172/0974-8369.1000274

Copyright: © 2016 Kumar MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

Mycobacterium tuberculosis is to be one of the world’s most deadly pathogens. The PA-824 nitroimidazole is a prodrug with an action activity against both hypoxic and replicating of Mycobacterium tuberculosis. PA-824 molecule was activated by a cofactor, which is a compound that binds to a protein. This prodrug was used as a ligand to bind with the protein PDB ID: 1XXO (Pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate). Pyridoxine 5-phosphate oxidase is called as the enzyme that catalyzes the B6 metabolism pathway by limits the rate step process. Docking analysis was performed on the protein 1XX0 along with ligand PA-824 using Autodock.

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