alexa Novel Antibacterial Polypeptide Laparaxin Produced by Lactobacillus paracasei Strain NRRL B-50314 Via Fermentation
ISSN:2157-7463

Journal of Petroleum & Environmental Biotechnology
Open Access

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Research Article

Novel Antibacterial Polypeptide Laparaxin Produced by Lactobacillus paracasei Strain NRRL B-50314 Via Fermentation

Siqing Liu1*, Brian J Wilkinson2, Kenneth M Bischoff1, Stephen R Hughes1, Joseph O Rich1 and Michael A Cotta3
1RPT Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, 1815 N. University St, Peoria, IL 61604, USA
2School of Biological Sciences, Illinois State University, Normal, IL 61791-4120 USA
3BER Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, 1815 N. University St, Peoria, IL 61604, USA
Corresponding Author : Dr. Siqing Liu
RPT Research Unit
National Center for Agricultural Utilization Research
Agricultural Research Service
United States Department of Agriculture
1815 N. University St, Peoria, IL 61604, USA
E-mail:[email protected]
Received April 11, 2012; Accepted April 25, 2012; Published April 27, 2012
Citation: Liu S, Wilkinson BJ, Bischoff KM, Hughes SR, Rich JO, et al. (2012) Novel Antibacterial Polypeptide Laparaxin Produced by Lactobacillus Paracasei Strain NRRL B-50314 Via Fermentation. J Pet Environ Biotechnol 3:121. doi:10.4172/2157-7463.1000121
Copyright: © 2012 Liu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study reports the production and characterization of a novel antibacterial polypeptide, designated laparaxin, which is secreted by Lactobacillus paracasei NRRL B-50314. Crude laparaxin has antibacterial activity against a wide variety of Gram-positive bacteria, including: lactic acid bacteria (Lactococcus lactis and Lactobacillus buchneri), food-borne pathogens (Listeria monocytogenes), gastrointestinal pathogens (Enterococcus faecalis), and opportunistic pathogens (Staphylococcus aureus methicillin-sensitive (MSSA) and methicillin resistant (MRSA) strains, a hetero-vancomycin-intermediate methicillin resistant strain (Hetero VISA also MRSA) MM66, and homogeneous vancomycin intermediate (Homo VISA). Using L. lactis as an indicator strain, the inhibitory activity of crude laparaxin was detected originally in early log phase, and the activity maximizes at the early stationary phase and remains stable after prolonged incubation. Laparaxin activity is stable after 30 min of incubation at 94°C. Higher concentrations of inhibitory activity are produced when glucose, fructose and sucrose are used as carbon-sources in growth media. Crude laparaxin has potential applications in food and feed industries, as well as in clinical and veterinary medicine.

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