Novel Therapeutics for Adverse Effects of Antitumor Therapy: The Promise of Multicomponent, Traditional Japanese Herbal Remedies
- *Corresponding Author:
- Toru Kono
Advanced Surgery Center, 3-1, N 33, E 14, Higashi-ku
Sapporo Higashi Tokushukai Hospital
Sapporo, Hokkaido 065-0033, Japan
E-mail: [email protected]
Received date: December 24, 2013; Accepted date: February 17, 2014; Published date: February 25, 2014
Citation: Kono T, Takeda H, Shimada M, Kase Y, Uezono Y (2014) Novel Therapeutics for Adverse Effects of Antitumor Therapy: The Promise of Multicomponent, Traditional Japanese Herbal Remedies. Carcinog & Mutagen S8:007. doi: 10.4172/2157-2518.S8-007
Copyright: © 2014 Kono T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In contrast to conventional single-target drugs, multi-component Kampo medicines are designed to achieve therapeutic effects through multiple drug targets. This article will discuss recent advances in mechanistic studies and the clinical effects of five representative Kampo formulations (hangeshashinto, daikenchuto, goshajinkigan, yokukansan and rikkunshito) for the treatment of adverse effects caused by anticancer drugs such as oral mucositis, diarrhea, neurotoxicity and abnormal behavior, for which western pharmaceuticals fail to adequately address.