alexa Oleic Acid and Diketopiperazines Produced by Marine Bac
ISSN: 2155-9546

Journal of Aquaculture Research & Development
Open Access

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Research Article

Oleic Acid and Diketopiperazines Produced by Marine Bacteria Reduce the Load of the Pathogen Vibrio parahaemolyticus in Argopecten purpuratus

Yanett Leyton1,2* and Carlos Riquelme1
1Centro de Bioinnovación, Laboratorio de Ecología Microbiana. Facultad de Recursos del Mar. Universidad de Antofagasta, Chile
2Programa de doctorado en Ciencias Aplicadas, Mención Sistemas Marinos Costeros, Facultad de Recursos del Mar, Universidad de Antofagasta, Chile
Corresponding Author : Yanett Leyton
Bioinnovation Center, Microbial Ecology Laboratory
Faculty of Marine Resources, Universidad de Antofagasta
Antofagasta, Chile
Tel: +56-55-637532
Fax: +56-55-637804
E-mail: [email protected]
Received January 09, 2013; Accepted March 20, 2013; Published March 30, 2013
Citation: Leyton Y, Riquelme C (2013) Oleic Acid and Diketopiperazines Produced by Marine Bacteria Reduce the Load of the Pathogen Vibrio parahaemolyticus in Argopecten purpuratus. J Aquac Res Development 4:179. doi:10.4172/2155-9546.1000179
Copyright: © 2013 Leyton Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The aquaculture industry must often deal in its cultures with bacterial contamination by Vibrio parahaemolyticus, which causes gastroenteritis in humans when they eat contaminated organisms. Until recently these pathogens were treated with antibiotics which are now forbidden because of their negative effects on humans and on the ecosystem. In the last few years there have been attempts to solve this problem by searching for active metabolites from antagonist bacteria. The objetive of this work was to evaluate the decrease of the load of the pathogen V. parahaemolyticus in Argopecten purpuratus scallops by the addition of oleic acid and diketopiperazines isolated from marine bacteria known for having an antibacterial effect against the pathogen, and with commercially available products similar to the molecular structures isolated from the bacteria. The decrease of the pathogen load was determined by the most probable number method from the absence in the samples of the gene tdh that codes for thermostable direct hemolysin (TDH), the main virulence factor in this species. The A. purpuratus bivalves treated with the oleic acid and diketopiperazines isolated from the bacteria showed preliminarily that they cause a reduction of the bacterial load of the V. parahaemolyticus pathogen. The same trend was seen when the scallops were treated with commercial oleic acid and diketopiperazines. Based on the inhibiting activity seen with the commercial products we suggest the possibility of experimenting with these products against V. parahaemolyticus or other pathogens in different commercially important organisms, mainly in depuration systems that require a short time (12 to 24 hours) to reduce the concentration of human pathogens like V. parahaemolyticus.

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