A 85-year-old Brazilian woman presented with a 3-months history of oral lesions. She reported a long use of hydrochlorothyazide and losartan for systemic arterial hypertension and levotiroxin for hypothyroidism. Additionally, she reported to have hepatitis C. The rest of her medical history was non-contributory. Physical examination revealed multiple white, reticulopapular lesions in bilateral buccal mucosa, tongue and gingiva. There was no regional lymphadenopathy. Laboratory studies including urinalysis, blood count and blood chemistry were all within the normal range.