Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces LifespanBozhkov AI*, Nikitchenko Yu V and Al-Bahadly Ali MM
Research Institute of Biology, V.N. Karazin Kharkov National University, 61022 Kharkov, Ukraine
- *Corresponding Author:
- Bozhkov AI
Research Institute of Biology
V.N. Karazin Kharkov National University
61022 Kharkov, Ukraine
E-mail: [email protected]
Received date: April 20, 2016; Accepted date: May 17, 2016; Published date: May 20, 2016
Citation: Bozhkov AI, Nikitchenko Yu V, Al-Bahadly Ali MM (2016) Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan. J Gerontol Geriatr Res 5: 309. doi:10.4172/2167-7182.1000309
Copyright: © 2016 Bozhkov AI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We investigated the role of metabolic memory in a choice of strategies for adaptation to stress influences. We used a model of rat overeating in early ontogenesis from birth to 21 days of life and investigated the maintenance of formed metabolic pattern in later ontogenesis. The following characteristics were measured: somatometric indicators, resistance of animals to a temperature stress of 32Ã¡ÂµÂC, thyroxin and triiodothyronine content in blood serum, NO-synthase activity, the content of lipid hydroperoxides and antioxidant enzymes in different organs in animals of 3, 20 and 31 months of age under standard conditions of maintenance in control animals and after overeating in the early ontogenesis. It is shown that the metabolic pattern formed on the background of overeating from birth to 21 days remains until the later stages of ontogeny. The forming metabolic pattern is characterized by elevated content of thyroxin, increase of NO-synthase activity in various tissues and particularly in the brain, a small increase of lipid hydroperoxides and reduced antioxidant activity of some enzymes. Animals that overeated in the early ontogenesis, are characterized by lower resistance to high temperatures and shorter life expectancy compared to the animals contained in the standard terms.