alexa Pathogenic Parameters Derived from Activated Platelets
ISSN: 2329-9088

Tropical Medicine & Surgery
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Research Article

Pathogenic Parameters Derived from Activated Platelets in Dengue Patients

Jih-Jin Tsai1,2,3*, Po-Chih Chen1,4,5, Li-Teh Liu6, Ko Chang1,2,3,7, Ju-Han Yao8, Hui-Mien Hsiao8, Kristina B Clark8,9, Yu Han Chen8, Alan Yi-Hui Hsu9 and Guey Chuen Perng8,9,10*

1 Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

2 Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

3 Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

4 Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

5 Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Taiwan

6 Department of Medical Laboratory Science and Biotechnology, College of Medicine and Life Science, Chung-Hwa University of Medical Technology, Taiwan

7 Department of Internal Medicine, Kaohsiung Municipal Hsaio-Kang Hospital, Kaohsiung, Taiwan

8 Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA

9 Department of Microbiology and Immunology, National Cheng Kung University, Medical College, Tainan, Taiwan

10 Center of Infectious Diseases and Signaling Research, National Cheng Kung University, Medical College, Tainan, Taiwan

*Corresponding Author:
Jih-Jin Tsai
Tropical Medicine Center, Kaohsiung Medical University Hospital
Kaohsiung, Taiwan
E-mail: [email protected]

Guey Chuen Perng
Department of Microbiology and Immunology, College of Medicine
National Cheng Kung University, Tainan, Taiwan
E-mail:[email protected]

Received Date: August 02, 2013; Accepted Date: August 27, 2013; Published Date: September 01, 2013

Citation: Tsai JJ, Chen PC, Liu LT, Chang K, Yao JH, et al. (2013) Pathogenic Parameters Derived from Activated Platelets in Dengue Patients. Trop Med Surg 1:142. doi: 10.4172/2329-9088.1000142

Copyright: © 2013 Tsai JJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Platelets have been recognized to be an integral part of human immune system. Hematologic disfunction, such as thrombocytopenia, is one of the most salient clinical features in dengue patients. Understanding the parameters released from activated platelets, involving in maintaining the delicate network, can provide a better picture of pathogenic cause of dengue. Ninety four dengue confirmed patients, 24 other febrile patients, and 12 healthy controls were enrolled to study. The parameters including the levels of polyphosphates, bradykinin, thyroxine, nitrite/ nitrate, platelet factor 4 (PF4), and serotonin, from the circulation of dengue patients were quantified by commercial ELISA kits and then compared to that from patients with other febrile illnesses, follow-up samples, and healthy controls. The following results were documented. Results 1. The levels of polyphosphates were on average 30% higher in acute dengue samples than healthy controls. 2. The levels of thyroxine, and nitrite/nitrate were significantly higher in acute dengue samples compared to that of other febrile, follow-up and healthy samples, while bradykinin was significantly lower. 3. The levels of PF4 were not different among samples of acute dengue, other febrile illness and follow-up, but were all significantly higher than the healthy controls. 4. The levels of serotonin were significantly higher in acute febrile stage compared to convalescent stage; while significantly lower than healthy subjects. The dynamic network of biochemical programs that coordinate to maintain hemostasis become unbalanced during and following dengue virus infection. Factors released from activated platelets may influence the vascular permeability

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