alexa Pattern of Adverse Drug Reactions Due to Cancer Chemoth
ISSN: 2329-6887

Journal of Pharmacovigilance
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Research Article

Pattern of Adverse Drug Reactions Due to Cancer Chemotherapy in a Tertiary Care Teaching Hospital in Eastern India

Anju Prasad1 , Pratyay Pratim Datta1 *, Jibak Bhattacharya2 , Chaitali Pattanayak1 , Ashok Singh Chauhan1 and Parbaty Panda1
1Department of Pharmacology, Hi-Tech Medical College and Hospital, Bhubaneswar, India
2Department of Radiotherapy, NRS Medical College and Hospital, Kolkata, India
Corresponding Author : Pratyay Pratim Datta, P.G
Resident, Department of Pharmacology
Hi-Tech Medical College and Hospital
Bhubaneswar, Flat 301, Bipasa Apartment
24/1/A S.S. Sen Road, Berhampore
Murshidabad, West Bengal
PIN-742101, India
Tel: +91-9433457247
E-mail: [email protected]
Received January 24, 2013; Accepted February 06, 2013; Published February 08, 2013
Citation: Prasad A, Datta PP, Bhattacharya J, Pattanayak C, Chauhan AS, et al. (2013) Pattern of Adverse Drug Reactions Due to Cancer Chemotherapy in a Tertiary Care Teaching Hospital in Eastern India. J Pharmacovigilance 1:107. doi: 10.4172/2329-6887.1000107
Copyright: © 2013 Prasad A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Introduction: Adverse drug reactions (ADRs) are a global problem adding to the economic burden of the society. Anti-cancer drugs are prone to cause ADRs and there is lack of pharmacovigilance data on such drugs. Therefore the present study was undertaken to monitor suspected ADRs in the radiotherapy unit of a tertiary care teaching hospital in Eastern India. Materials and methods: The present study was done in the Radiotherapy Department of a tertiary care teaching hospital in Eastern India from March, 2012 to August, 2012 among the patients receiving cancer chemotherapy. It was a hospital based prospective observational study. ADRs were documented in Suspected Adverse Drug Reaction reporting form designed by Centre for Drug Standard Control Organizationand causality assessment was done using Naranjo scale. Results: 87% of the total patients receiving cancer chemotherapy developed ADRs. Most common ADRs found were nausea and vomiting followed by neutropenia. Cisplatin, Cyclophosphamide, 5-Fluoro uracil, Paclitaxel and Adriamycin were common drugs causing ADRs. 62% of the ADRs were probable according to Naranjo scale. Conclusion: The cancer chemotherapeutic drugs are associated with varied adverse effects. However, early detection of drug toxicity helps to modify the doses or the drug regimen to minimize toxic effects.

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