Performance of Several Bioequivalence Metrics for Assessing the Rate and Extent of Absorption
- *Corresponding Author:
- Dr. Husam A. Bayoud
Arts and Sciences Unit
Fahad Bin Sultan University
Tabuk, Kingdom of Saudi Arabia
E-mail: [email protected]
Received Date: July 20, 2011; Accepted Date: August 26, 2011; Published Date: August 28, 2011
Citation: Bayoud HA, Awad AM (2011) Performance of Several Bioequivalence Metrics for Assessing the Rate and Extent of Absorption. J Bioequiv Availab 3: 174-177. doi: 10.4172/jbb.1000080
Copyright: © 2011 Bayoud HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In this paper the problem of interest is the bioequivalence metrics and their role in assessing the rate and extent of absorption ratios of two drug formulations. Several bioequivalence metrics were proposed by several authors in the literature to estimate the similarity or dissimilarity of two drug formulations. The existing bioequivalence metrics are reviewed. A new bioequivalence metric is proposed and motivated. The performance, in terms of the statistical power, of the previously proposed and the new bioequivalence metrics is also evaluated by simulating cross-over bioequivalence trials.