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ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Research Article

Plasma Transfusion and Lung Injury in the Pediatric Intensive Care Unit

Robert A. Niebler1*, Melissa Christensen2 and Jennifer McArthur1

1Medical College of Wisconsin, Department of Pediatrics, Division of Critical Care, Milwaukee, Wisconsin, USA

2Medical College of Wisconsin, Department of Surgery, Division of Pediatric Surgery, Milwaukee, Wisconsin, USA

*Corresponding Author:
Robert A. Niebler
9000 W. Wisconsin Ave.
P.O. Box 1997 (MS 681)
Milwaukee, WI
USA, 53201-1997
Tel: 414-266-3360
Fax: 414- 266-3563
E-mail: [email protected]

Received date: April 02, 2012; Accepted date: April 25, 2012; Published date:May 02, 2012

Citation: Niebler RA, Christensen M, McArthur J (2012) Plasma Transfusion and Lung Injury in the Pediatric Intensive Care Unit. J Blood Disord Transfus 3:122. doi: 10.4172/2155-9864.1000122

Copyright: © 2012 Niebler RA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: This study investigated if there was an association between Fresh Frozen Plasma (FFP) transfusion and severity of lung injury as measured by the Oxygenation Index (OI) in a Pediatric Intensive Care Unit (PICU) population.

Methods: This was a retrospective cohort study of 178 patients who had data available to calculate the OI (OI = mean airway pressure × FiO2 × 100 / Pa O2 ). 166 patients were transfused with FFP and 12 control patients with an INR > 1.5 who were not transfused with FFP were included. The OI was calculated at time 0 (prior to transfusion or at time of peak INR in controls); 6; 24; and 48 hours later.

Results: Change in the OI was -0.2 ± 4.1, 0.3 ± 4.9, and 0.0 ± 6.8 at 6, 24, and 48 hours respectively in the transfused group and 0.3 ± 0.7, 1.5 ± 5.4, and 3.3 ± 9.5 at 6, 24, and 48 hours respectively in the control group. Multivariate analysis failed to find a significant association between FFP transfusion and a change in the OI.

Conclusion: FFP transfusion was not associated with a change in the severity of lung injury as measured by the OI.


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