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Life-Threatening Autoimmune Hemolytic Anemia Treated with Manual Whole Blood Exchange with Rapid Clinical Improvement | OMICS International | Abstract
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Research Article

Life-Threatening Autoimmune Hemolytic Anemia Treated with Manual Whole Blood Exchange with Rapid Clinical Improvement

Laura Cooling1*, Grace Boxer2 and Richard Simon2

1Department of Pathology, University of Michigan, Ann Arbor, MI, USA

2Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

*Corresponding Author:
Laura Cooling
Associate Professor, Pathology, University of Michigan Hospitals
2F225 UH Blood Bank, Box 0054
1500 East Medical Center Drive, Ann Arbor, MI 48109-0054, USA
Tel: 734-936-0695
Fax: 734-936-6855
E-mail: [email protected]

Received date: July 25, 2013; Accepted date: October 08, 2013; Published date: October 12, 2013

Citation: Cooling L, Boxer G, Simon R (2013) Life-Threatening Autoimmune Hemolytic Anemia Treated with Manual Whole Blood Exchange with Rapid Clinical Improvement. J Blood Disord Transfus 4:163. doi:10.4172/2155-9864.1000163

Copyright: © 2013 Cooling L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Severe autoimmune hemolytic anemia, with high titer panagglutinins, can present with severe intra-and extravascular hemolysis, complicated by renal failure, volume overload, hypertriglyceridemia, pancreatitis and multiorgan failure. We present a case of life-threatening warm autoimmune hemolytic anemia in a 19 year old male, refractory to steroids and splenectomy, with ongoing severe hemolysis, in vivo and in vitro autoagglutination, worsening hypoxia, methemoglobinemia, renal insufficiency, and hypertriglyceridemia. The patient underwent a single manual whole blood exchange with reconstituted whole blood (50% final hematocrit). The post-exchange hemoglobin was 7.7 gm/dL, with complete resolution of RBC autoagglutination, increased platelet count (20% ) and marked decreases in plasma free hemoglobin (43%), methemoglobin (9%), percent FiO2 (40%), creatinine (30%), triglycerides (66%), bilirubin (56%) and autoantibody titer (1000 to 256). The patient was extubated shortly after WBEx with minimal hemolysis and RBC transfusion support over the next 2 weeks.


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