alexa Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System | Abstract
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System

Mahipal Reddy Donthi, Narendar Reddy Dudhipala, Devendhar Reddy Komalla, Dinesh Suram and Nagaraju Banala*

University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India

*Corresponding Author:
Nagaraju Banala
Assistant professor, Department of Pharmaceutics
University College of Pharmaceuical Sciences
Kakatiya University, Warangal, Telangana, India
Tel: 8099722523
E-mail: [email protected]; [email protected]

Received Date: September 03, 2015; Accepted Date: October 15, 2015; Published Date: October 22, 2015

Citation: Donthi MR, Dudhipala NR, Komalla DR, Suram D, Banala N (2015) Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System. J Bioequiv Availab 7:279-283. doi:10.4172/jbb.1000254

Copyright: © 2015 Donthi MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ketoprofen is a non steroidal anti inflammatory drug and famotidine is a H2 receptor antagonist. The patients with immune mediated diseases like rheumatoid and osteo arthritis treated with ketoprofen, which induces ulcers in the stomach by the stimulation of H2 receptor and inhibition of COX-I enzyme. Upon the addition of famotidine suppress the acid secretion in the stomach, this mechanism was implemented by the delivery system at different time periods with different site specificity in the GIT and drug release was programmed according to the pH dependent solubility and also includes reducing the cost. Hence, the content of this investigation was to prepare and evaluate the famotidine floating and ketoprofen enteric coated mini tablets capsulated in a single unit dosage form. The tablets were prepared by wet granulation method using HPMC K100M and HPMC K15M as release controlling polymers. Pre compression and post compression parameters of prepared tablets were evaluated as per pharmacopeial methods. From the in vitro release studies, optimized formulation of famotidine floating and ketoprofen enteric coated tablets has shown 98.02 ± 2.79% and 97.5 ± 2.08% release in 12 h, respectively. Floating lag time of optimized famotidine formulation was 13 sec with total floating time of >12 h and ex vivo retention time was found to be 12 h. SEM studies were conducted to the optimized ketoprofen enteric coating tablet and found to be smooth surface. In vivo imaging studies revealed that tablets remained in the stomach for 8h for famotidine and 12 h in intestinal region for ketoprofen tablet. DSC studies revealed that there was no interaction between the drug and excipients used for the formulation development.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version