alexa Prevalence and Risk Factors of Cryptosporidium Infectio
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

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Research Article

Prevalence and Risk Factors of Cryptosporidium Infection in Children Hospitalized for Diarrhea in Guangzhou, China

Shouyi Chen1, Edward Rob Atwill2,3, Fei Zhong1, Yuehong Wei1, Shuiping Hou1, Juntao Li1, Conghui Xu1, Chengling Xiao3, Zhicong Yang1 and Xunde Li2,3*

1Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong Province, China

2Department of Population Health and Reproduction, University of California Davis, California, USA

3Western Institute for Food Safety and Security, University of California Davis, California, USA

*Corresponding Author:
Xunde Li
Department of Population Health and Reproduction
University of California Davis, California, USA
E-mail: [email protected]

Received Date: May 03, 2017; Accepted Date: May 11, 2017; Published Date: May 16, 2017

Citation: Chen S, Atwill ER, Zhong F, Wei Y, Hou S, et al. (2017) Prevalence and Risk Factors of Cryptosporidium Infection in Children Hospitalized for Diarrhea in Guangzhou, China. J Bacteriol Parasitol 8:308. doi: 10.4172/2155-9597.1000308

Copyright: ©2017 Chen S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

This study was conducted to determine the prevalence, species and risk factors of Cryptosporidium infection in children hospitalized for diarrhea in Guangzhou region of China. A cross-sectional study was conducted to assess the prevalence and risk factors of Cryptosporidium infection in children (2 weeks to 10 years old) who were hospitalized for diarrhea. Cryptosporidium oocysts were detected using direct immunfluorescent assay and species were determined by sequencing a fragment (~800 bp) of the 18S rRNA gene. A questionnaire contains host, sociodemographic, family, hygiene, diet, zoonotic, and environmental risk factors was administered to patients to identify key factors associated with infections. The observed Cryptosporidium prevalence was 6.9% and the true prevalence was estimated to be 9.0%. Cryptosporidium infection was similar between male (7.4%) and female (6.1%) children and negatively associated with age (i.e., infection was more likely in younger children). Infections in children were significantly associated with family members’ diarrhea within past one month. Infection in children in suburban hospitals (7.8%) was significantly higher than that in urban hospitals (2.1%). The overall prevalence of Cryptosporidium in rainy season was significantly higher than that in non-rainy seasons. DNA sequences of the 18S rRNA gene from infected children were 99.12% to 100% identical to sequences in the GenBank of C. parvum isolates from humans and animals. Future works should determine the sources of zoonotic Cryptosporidium and routes of waterborne exposure in the rainy season in this region.

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