alexa Proteomic Profile of Circulating Immune Complexes in Dengue Infected Patients
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Research Article

Proteomic Profile of Circulating Immune Complexes in Dengue Infected Patients

Nguyen Tien Huy1,2#, Huynh Trung Trieu1#,, Kenta Okamoto3, Tran Thi Hai Ninh1, Tran Thi Ngoc Ha1, Kouichi Morita3, Vu Thi Que Huong3, Nguyen Thi Phuong Lan4, Tran Thi Thuy5, Cao Thi Phi Nga6, Mihoko Kikuchi1, Naotaka Kuroda7, Juntra Karbwang2, Kaname Ohyama7,8* and Kenji Hirayama1,9*

1Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

2Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

3Department of Virology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

4Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City, Vietnam

5Children’s Hospital No.2, Ho Chi Minh City, Vietnam

6Center for Preventive Medicine, Vinh Long, Vietnam

7Course of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

8Nagasaki University Research Centre for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki, Japan

9Global COE program, Nagasaki University, Japan

#These authors contributed equally to this work

*Corresponding Author:
Kaname Ohyama
Course of Pharmaceutical Sciences
Nagasaki University
Research Centre for
Genomic Instability and Carcinogenesis
Nagasaki University, Japan
E-mail: [email protected]

Kenji Hirayama
Department of Immunogenetics
Institute of Tropical Medicine (NEKKEN)
Nagasaki University, Japan
E-mail: [email protected]

Received Date: June 13, 2013; Accepted Date: June 24, 2013; Published Date: June 27, 2013

Citation: Huy NT, Trieu HT, Okamoto K, Ninh TTH, Ha TTN, et al. (2013) Proteomic Profile of Circulating Immune Complexes in Dengue Infected Patients. J Trop Dis 1:109. doi: 10.4172/2329-891X.1000109

Copyright: © 2013 Huy NT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Dengue virus is a flavivirus that causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), and Dengue Shock Syndrome (DSS), a serious public health problem in many countries. An auto-immune response is thought to play an important role in the pathogenesis of severe dengue and the increased level of Circulating Immune Complexes (CIC) in dengue infected patients. Therefore, a proteomic analysis of proteins in the CIC can provide a better knowledge of the pathogenesis and a potential biomarker for severe dengue. A proteomic strategy based immune complexome analysis was performed to analyze the composition of CIC from plasma of fifteen dengue infected patients and five healthy control children. A total of 111 proteins were identified in the CIC from all individuals, with 17 proteins shared by healthy, DF, DHF, and DSS groups. All detected proteins were of similar relative proportion in the CIC of healthy, DF, DHF, and DSS groups. The results also revealed a high similarity of CIC profiles between four groups of subjects when classifying identified proteins according to cellular components or functional protein categories. These results showed no evidence to support the roles of CIC mediated by auto-immune response in the pathogenesis of severe dengue.

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