alexa Pseudomonas Keratitis, a Review of Where Wehave Been an
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
Open Access

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Research Article

Pseudomonas Keratitis, a Review of Where Wehave Been and What Lies Ahead

Alicia Eby M1 and Linda Hazlett D2*

1Kresge Eye Institute, Wayne State University, Detroit Michigan, United States

2Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit Michigan, United States

*Corresponding Author:
Linda Hazlett D
Department of Anatomy and Cell Biology
Wayne State University School of Medicine
Detroit Michigan, United States
Tel: +1 313-577-1335
E-mail: [email protected]

Received Date: December 03, 2015; Accepted Date: December 14, 2015; Published Date: December 21, 2015

Citation: Alicia Eby M, Linda Hazlett D (2016) Pseudomonas Keratitis, a Review of Where We’ve Been and What Lies Ahead. J Microb Biochem Technol 8: 009-013. doi:10.4172/1948-5948.1000254

Copyright: © 2015 Alicia Eby M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Microbial keratitis can result in significant vision loss secondary to corneal scarring or surface irregularity. If untreated, corneal perforation and endophthalmitis can occur, resulting in loss of the eye. Damage to the cornea can occur in as little as 24 hrs and the most aggressive infections are often caused by P. aeruginosa which is a highly virulent opportunistic pathogen. This bacterium is highly effective at evading the immune response and blunting it via several mechanisms. Normally the innate immune system provides defense with neutrophils which are recruited within as little as 6-12 hrs of infection travelling from limbal vessels via the tear film to the site of the infection. These cells play a critical role in limiting bacterial proliferation as well as protecting host tissue from destruction, but if they persist locally they are detrimental, inducing additional tissue damage. Evasion is aided in part due to the bacterial glycocalyx which functions to inhibit migration and function of neutrophils. Beyond this first line of defense, the complex story unravels involving secreted exotoxins S, T and U, the role of TLRs, chemokines and cytokines including interleukins 1, 6, 10, 12, 17 and 18, IFN-γ as well as CD4+ T cells, antigen presenting cells (Langerhans cells) and macrophages. With a complex interplay between bacteria and host, infection with P. aeruginosa has a hallmark ability to incite an exuberant immune response, propagating local tissue damage. It is facile to appreciate just how difficult it has been to target precise susceptibilities, treatment strategies and models of pathogenesis, given the elaborate mechanisms involved in both bacterial action and more importantly host inflammation. Herein we will review some of the major breakthroughs in our understanding of the pathogenesis of this bacterium and discuss recent novel therapeutic targets.


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