Reach Us +1-504-608-2390
Reduction of Hepatotoxicity Induced by Acetaminophen Overdoses in a Mouse Model of Inflammation Induced by Freund's Adjuvants | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Reduction of Hepatotoxicity Induced by Acetaminophen Overdoses in a Mouse Model of Inflammation Induced by Freund's Adjuvants

Noel Pérez García1, Onel Fong Lores2, Deivys Portuondo Fuentes3, Damiana Téllez Martínez4, Juan Betancourt Hernandez2, Lidia Páez Rivas1, Oliver Pérez Martin5 and Alexander Batista-Duharte2,3*

1University of Havana, Faculty of Biochemistry, Havana City, Cuba

2Toxicology and Biomedicine Center (TOXIMED), Medical Sciences University, Santiago de Cuba, Cuba

3Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas, Araraquara, SP, Brazil

4Faculty of Chemical Enginery, Oriente Universitym, Ave Las Americas, Santiago de Cuba, Cuba

5University of Medical Science, Department of Immunology, Havana, Cuba

*Corresponding Author:
Alexander Batista Duharte
Immunotoxicology Laboratory, Toxicology and Biomedicine Center (TOXIMED)
Medical Sciences University, P.O. Box 4033 National Highway
Km 1 1/2. Santiago de Cuba Cuba
Tel: 532264 3796, 5322643926
Fax: 5322643864, 5322687188
E-mail: [email protected]

Received date: June 05, 2014; Accepted date: July 11, 2014; Published date: July 18, 2014

Citation: García NP, Lores OF, Fuentes DP, Martínez DT, Hernandez JB, et al. (2014) Reduction of Hepatotoxicity Induced by Acetaminophen Overdoses in a Mouse Model of Inflammation Induced by Freund´s Adjuvants. J Allergy Ther 5:183. doi: 10.4172/2155-6121.1000183

Copyright: © 2014 García NP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acetaminophen (APAP) is often used as an analgesic and antipyretic during the inflammatory process. Its toxicity in overdoses depends on the integrity of the hepatic cytochrome P450 (CYP). The oxidative drug metabolism mediated by CYP can be inhibited during inflammatory diseases or after use of immuno-stimulants drugs and vaccines. The objective of this work was to evaluate if inflammation is able to modulate the toxicity of APAP. Five female Balb/c mice were injected subcutaneously with Freund Complete Adjuvant (FCA), and boosted with Freund’s Incomplete Adjuvant (FIA) at 14th day. Then, they were treated with 360 mg/kg of acetaminophen orally during the 14th, 15th and 16th days. Convenient control groups were included with APAP administration without immuno-stimulation. Serum levels of IL-1β, TNFα, IFNγ, α-1-acid glycoprotein (α-1-AGP), alanine transaminase (ALT), aspartic acid aminotransferase (AST), lactate dehydrogenase (LDH) and hepatic CYP2E1 expression were measured. Inoculation site of adjuvants and liver histopathological responses were also evaluated. FCA/FIA injection produced acute inflammatory response in the inoculation site and increased serum levels of the pro-inflammatory cytokines, α-1-AGP and LDH with reduction of hepatic CYP2E1 expression. A reduction of liver damage induced by APAP overdoses was also observed, suggesting that inflammatory processes can be protective against APAP hepatotoxicity.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version