alexa Relationship between Mycobacterium Tuberculosis and Hookworm Infections among School Children in Mbita, Kenya
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Research Article

Relationship between Mycobacterium Tuberculosis and Hookworm Infections among School Children in Mbita, Kenya

Manabu Inoue1*, Sachiyo Nagi2, Evans Chadeka2, Faith Mutungi3, Mayuko Osada-Oka1,4, Kenji Ono5, Tetuya Oda5, Michinori Tanaka5, Yuriko Ozeki1,6, Kalenda Dan Justin Yombo2, Mayuko Okabe7, Mamiko Niki1, Yukio Hirayama1, Mitsuru Fukui8, Kazuo Kobayashi7, Makoto Matsumoto5, Masaaki Shimada9, Satoshi Kaneko9, Hisashi Ogura10, Yoshio Ichinose9, Sammy M Njenga3, Shinjiro Hamano2and Sohkichi Matsumoto1,11*

1Departments of Bacteriology and Virology, Osaka City University Graduate School of Medicine, Japan

2Department of Parasitology, Institute of Tropical Medicine (NEKKEN) and the Global Center of Excellence, Nagasaki University, Japan

3Eastern and Southern Africa Centre of International Parasite Control (ESACIPAC), Kenya Medical Research Institute, Nairobi, Kenya

4Food Hygiene and Environmental Health Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Japan

5Microbiological Research Institute, Otsuka Pharmaceutical, Kagasuno, Kawauchi-cho, Japan

6Department of Food and Nutrition, Sonoda Women’s University, Japan

7Department of Immunology, National Institute of Infectious Diseases, Japan

8Department of Statistics, Osaka City University Graduate School of Medicine, Japan

9Nagasaki University Nairobi Research Station, NUITM-KEMRI Project, Nagasaki University, Japan

10Departments of Virology, Osaka City University Graduate School of Medicine, Japan

11Departments of Bacteriology, Niigata University School of Medicine, Japan

*Corresponding Author:
Manabu Inoue
Department of Bacteriology
Osaka City University Graduate School of Medicine, Japan
Tel: +81-6-6645-3745
Fax: +81-6-6645-3746
E-mail: [email protected]

Sohkichi Matsumoto
Department of Bacteriology
Osaka City University Graduate School of Medicine, Japan
Tel: +81-6-6645-3745
Fax: +81-6-6645-3746
E-mail: [email protected]

Received Date: September 02, 2013; Accepted Date: October 18, 2013; Published Date: October 21, 2013

Citation: Inoue M, Nagi S, Chadeka E, Mutung F, Osada-Oka M (2013) Relationship between Mycobacterium Tuberculosis and Hookworm Infections among School Children in Mbita, Kenya. J Trop Dis 1:120. doi: 10.4172/2329-891X.1000120

Copyright: © 2013 Inoue M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Tuberculosis (TB) remains a serious threat for human health. The majority of TB cases arise from latent Mycobacterium tuberculosis infection (LTBI). Therefore, latent M. tuberculosis infection (LTBI) is a major reservoir of the pathogen, and every effort thus should be made to diagnose LTBI to ensure completion of the treatment of it. TB is endemic throughout most of the tropics, in which parasitic infections are prevalent as well. It was reported that Helminth infection, including hookworm, is a risk of active TB, but its effect on the establishment of LTBI is unknown. In this study, we conducted a cross-sectional survey of LTBI and parasitic infections among 240 children from schools situated along the shores of Lake Victoria in Mbita district, Kenya. Blood samples were analyzed for LTBI and enteric parasite infections. Among the 240 children examined, 75 (31.3 %) were found to have LTBI. Of the 75 children with LTBI, 10 children (13.3%) were found to be positive for hookworm eggs (odds ratio: 3.02; 95% confidence interval: 1.14-7.99). Our study suggests for the first time that hookworm infection is associated with not only active TB but also LTBI.

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