R-Spondin 1 Regulates WNT Signaling Pathway by Antagonizing the Function of Dickkopf Homolog 1Yang Wang1, Bingqiang Zhang2 and Wei Zou2,3*
- *Corresponding Author:
- Wei Zou
Expert Work station, Restore Life Science Co
Qingdao, College of Life Science
Liaoning Normal University, Dalian, PR China
E-mail: [email protected]
Received date: December 19, 2016; Accepted date: January 11, 2017; Published date: January 13, 2017
Citation: Wang Y, Zhang B, Zou W (2017) R-Spondin 1 Regulates WNT Signaling Pathway by Antagonizing the Function of Dickkopf Homolog 1.Single Cell Biol 6:155. doi:10.4172/2168-9431.1000155
Copyright: © 2017 Wang Y, et al. This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The WNT family of secreted proteins play important roles in diverse biological processes, including development, proliferation, and differentiation, which regulate various diseases, such as prostate cancer, breast cancer, glioblastoma, type II diabetes and others. The WNT ligands could activate two major intracellular pathways: known as the canonical pathway which is β-catenin-dependent, and non-canonical pathway which is β-catenin-independent.