alexa Rifampicin-loaded Silver-starch Nanocomposite for the Treatment of Multi-resistant Tuberculosis
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Rifampicin-loaded Silver-starch Nanocomposite for the Treatment of Multi-resistant Tuberculosis

Isimi Christianah1, Asha Rodrigues2, Okafor Ijeoma1, Okoh Judith1, Aboh Mercy3 and Emeje Martins Ochubiojo1*

1National Institute for Pharmaceutical Research and Development, Centre for Nanomedicine and Biophysical Drug delivery, Abuja, Nigeria

2Physical and Materials Chemistry Division, National Chemical Laboratory, Pune, India

3National Institute for Pharmaceutical Research and Development, Department of Microbiology and Biotechnology, Abuja, Nigeria

*Corresponding Author:
Emeje Martins Ochubiojo
National Institute for Pharmaceutical Research and Development
Centre for Nanomedicine and Biophysical Drug delivery
Abuja, Nigeria
Tel: +2348037035738
E-mail: [email protected]

Received date March 29, 2016; Accepted date April 13, 2016; Published date April 25, 2016

Citation: Christianah I, Rodrigues A, Ijeoma O, Judith O, Mercy A, et al. (2016) Rifampicin-loaded Silver-starch Nanocomposite for the Treatment of Multi-resistant Tuberculosis. J Nanomed Nanotechnol 7:374. doi:10.4172/2157-7439.1000374

Copyright: © 2016 Christianah I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Extraction, purification and synthesis of acetylated cassava starch was undertaken. The degree of modification for the acetylated (modified) starch was calculated to be 0.03. Physicochemical indices interrogated were all significantly (P<0.05) affected by the acetylation. Microstructural studies revealed starches that were predominantly polygonal in shape. The FTIR results confirmed introduction of an acetyl group with a new band at 1728 cm-1. The results further show that, the modification did not degrade the granule morphology, but x-ray pattern showed increased crystallinity in the acetylated derivative. Thermogravimetric analysis and differential scanning calorimetry revealed 2 phase decomposition of both starches and improved gelation capacity with new peaks respectively. Rifampicin (RIF) loaded starch-stabilized silver nanoparticles yielded good mean particle size (248 nm), polydispersity index (0.276) and zeta potential (18.68 mV). There was a significant (P<0.01) sustained release of RIF from the nano formulations up to 14.0 h. Antimicrobial susceptibility tests show that, the nano formulation exhibited good antimicrobial activity. It is therefore concluded that, acetylated cassava starch could be a good stabilizer and vehicle for drug delivery.

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