alexa Serum Fatty Acid Synthase as a Marker of Esophageal Neoplasia
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

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Research Article

Serum Fatty Acid Synthase as a Marker of Esophageal Neoplasia

Hajime Orita1,2*, Malcolm Brock5, Yoshimi Iwanuma2, Kazunori Simada4, Hiroyuki Daida4, Okio Hino3, Yoshiaki Kajiyama2 and Masahiko Tsurumaru2

1Department of Surgery, Juntendo Shizuoka hospital, Shizuoka, Shizuoka, Japan

2Department of Esophageal and Gastroenterological Surgery, Juntendo University School of Medicine, Tokyo, Japan

3Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan

4Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan

5Department of Surgery, Johns Hopkins School of Medicine, Baltimore, USA

*Corresponding Author:
Hajime Orita
Department of Surgery
Juntendo Shizuoka Hospital
Shizuoka, Japan
Tel: 055-948-3111
Fax: 055-946-0514
E-mail: [email protected]

Rec date: Jan 8, 2016; Acc date: Feb 8; 2016; Pub date: Feb 11, 2016

Citation: Orita H, Brock M, Iwanuma Y, Simada K, Daida H, et al. (2016) Serum Fatty Acid Synthase as a Marker of Esophageal Neoplasia. Hereditary Genet 5:160. doi:10.4172/2161-1041.1000160

Copyright: © 2016 Orita H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Fatty Acid Synthase (FAS) is highly expressed in many human cancers. Previously, we reported that FAS is expressed at very high levels in esophageal cancer, and that the growth of these cancers can be inhibited by pharmacological agents that target this enzyme. We also have reported that this enzyme is overexpressed not only in tissue, but also in serum in patients with various cancers. In this present analysis, we investigate the serum level of this enzyme in patients, and consider whether FAS can be a prognositc tumor marker or one of early detection.
Materials and Methods: By using an ELISA kit, we measured the serum levels of FAS in 154 patients, who underwent surgical resection of esophageal cancer at the Juntendo Hospital in Tokyo, Japan. We also measured the serum FAS levels of 153 healthy volunteers recruited as normal controls from a cardiology research group. Finally, we considered how FAS levels correlated with pathological and clinical data. Results: Serum FAS levels in esophageal cancer patients were significantly higher than in healthy control subjects(13.2 ug/ml vs. 2.3 ul/ml, respectively). FAS levels did not correlate with clinical or-pathological data.
Conclusions: Serum FAS levels are expressed at significantly high levels in human esophageal carcinomas. FAS serum levels may be a tumor marker candidate for early esophageal cancer detection.

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