alexa Severe Asthma: Anti-IgE or Anti-IL-5?
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

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Review Article

Severe Asthma: Anti-IgE or Anti-IL-5?

Petros Bakakos1* and Stelios Loukides2

1Department of Respiratory Medicine, University of Athens, Greece

2Department of Respiratory Medicine, University of Athens, Greece

*Corresponding Author:
Petros Bakakos
Department of Respiratory Medicine
University of Athens, Greece
Tel: +30 210 725 2057
E-mail: [email protected]

Received Date: October 07, 2015 Accepted Date: November 09, 2015 Published Date: November 15, 2015

Citation: Bakakos P, Loukides S (2015) Severe Asthma: Anti-IgE or Anti-IL-5?. J Allergy Ther 6:223. doi: 10.4172/2155-6121.1000223

Copyright: © 2015 Bakakos P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Asthma is a common disease affecting more than 300 million people worldwide [1]. According to the recent ERS/ATS consensus severe asthma is defined as asthma that requires treatment with high dose Inhaled corticosteroids (ICS) plus one more controller (and/or oral corticosteroids) in order to be controlled or remains uncontrolled despite the above treatment or becomes uncontrolled with the reduction of high dose ICS or oral corticosteroids [2]. It is a prerequisite that the correct diagnosis of asthma has been confirmed and comorbidities have been identified and treated properly [2]. It is also extremely important to check inhaler technique and ensure good adherence to treatment. Current GINA document suggests that a referral to a specialist with expertise in the management of severe asthma is strongly encouraged for patients not controlled with treatment step 3 [1].

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