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ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Research Article

Solubility and Dissolution Improvement of Aceclofenac using Different Nanocarriers

Faiyaz Shakeel1,*, Wafa Ramadan1 and Sheikh Shafiq2

1Department of Pharmaceutics, Faculty of Pharmacy, Al-Arab Medical University, Benghazi, Libya

2New Drug Delivery System (NDDS), Zydus Cadila Healthcare Ltd, Ahemdabad, India

*Corresponding Author:
Dr Faiyaz Shakeel
Department of Pharmaceutics
Faculty of Pharmacy
Alarab Medical University
Benghazi-5341, Libya
Phone : 00218-913899028
E-mail : [email protected]

Received Date: July 02, 2009; Accepted Date: July 06, 2009; Published Date: July 07, 2009

Citation: Shakeel F, Ramadan W, Shafiq S (2009) Solubility and Dissolution Improvement of Aceclofenac using Different Nanocarriers. J Bioequiv Availab 1: 039-043. doi: 10.4172/jbb.1000007

Copyright: © 2009 Shakeel F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim of the present investigation was to improve solubility and dissolution of the lipophilic drug aceclofenac using three nanocarriers namely nanoemulsion, solid lipid nanosuspension and polymeric nanosuspension. The solubility of aceclofenac in distilled water and di fferent nanocarriers was determined using the UV sp ectropho- tometer method at the wavelength of 274 nm. Dissolu tion studies of pure aceclofenac suspension and its nanocarriers were performed using USP dissolution a pparatus in distilled water. The highest solubility (198.53 mg/ml) as well as % dissolution (99.5) of aceclofen ac was obtained with nanoemulsion formulation as co mpared to lipid and polymeric nanosuspension. The results of solubility and dissolution were highly significa nt in nanoemulsion as compared to lipid and polymeric nan osuspension (P<0.01). Dissolution profile of aceclo fenac in lipid and polymeric nanosuspension was significant as compared to pure aceclofenac suspension (P<0.05) . These results indicated that nanoemulsion is a promising nanocarrier as compared to lipid and polymeric nano suspension for solubility and dissolution enhancement of acecl ofenac.

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