alexa Soluble Epoxide Hydrolase: Potential Target for Inflammation and Inflammation-Driven Cancer | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

Soluble Epoxide Hydrolase: Potential Target for Inflammation and Inflammation-Driven Cancer

Chao Lou, Liping Zhang, Xiaobing Wang, Xiaoping Ma, Cuiyun Qin, Wei Li, Ting Jia, Qing Nan and Rong Qiang*

Department of Genetics, Northwest Women’s and Children’s Hospital, Xi’an, PR China

*Corresponding Author:
Rong Qiang
Department of Genetics
Northwest Women’s and Children’s Hospital, Xi’an, PR China
Tel: +862987234790
E-mail: [email protected]

Received date: February 28, 2017; Accepted date: May 16, 2017; Published date: May 22, 2017

Citation: Lou C, Zhang L, Wang X, Ma X, Qin C, et al. (2017) Soluble Epoxide Hydrolase: Potential Target for Inflammation and Inflammation-Driven Cancer. J Carcinog Mutagen 8:294. doi: 10.4172/2157-2518.1000294

Copyright: © 2017 Lou C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Arachidonic acid can be catalyzed by three different kind of metabolizing enzyme: cyclooxygenase (COX), lipoxygenase (LOX) and/or cytochrome P450 (CYP), and they produce prostaglandins, monohydroxys, leukotrienes and epoxyeicosanoids respectively. Through the cytochrome P450 pathway, arachidonic acid can be converted to two kinds of eicosanoid acids: epoxyeicosanoids acid (EET) by cytochrome P450 and hydroxyeicosatetraenoic acids (HETEs) formed by CYP α-oxidases.

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