Soluble Epoxide Hydrolase: Potential Target for Inflammation and Inflammation-Driven Cancer

Chao Lou; Liping Zhang; Xiaobing Wang; Xiaoping Ma; Cuiyun Qin; Wei Li; Ting Jia; Qing Nan; Rong Qiang

doi:10.4172/2157-2518.1000294

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Abstract

Soluble Epoxide Hydrolase: Potential Target for Inflammation and Inflammation-Driven Cancer

Chao Lou, Liping Zhang, Xiaobing Wang, Xiaoping Ma, Cuiyun Qin, Wei Li, Ting Jia, Qing Nan and Rong Qiang

Arachidonic acid can be catalyzed by three different kind of metabolizing enzyme: cyclooxygenase (COX), lipoxygenase (LOX) and/or cytochrome P450 (CYP), and they produce prostaglandins, monohydroxys, leukotrienes and epoxyeicosanoids respectively. Through the cytochrome P450 pathway, arachidonic acid can be converted to two kinds of eicosanoid acids: epoxyeicosanoids acid (EET) by cytochrome P450 and hydroxyeicosatetraenoic acids (HETEs) formed by CYP α-oxidases.