alexa Strategies to Improve the Anti-Cancer Properties of Gold(III) Complexes | OMICS International
ISSN: 2329-6798

Modern Chemistry & Applications
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Review Article

Strategies to Improve the Anti-Cancer Properties of Gold(III) Complexes

Raymond Wai-Yin Sun1,2*
1Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
2Department of Chemistry, Shantou University, Guangdong 515063, P.R. China
 
Corresponding Author : Raymond Wai-Yin Sun
Department of Chemistry
The University of Hong Kong
Pokfulam Road, Hong Kong, China
Tel: +852-2859-8965
E-mail: [email protected]
Received April 05, 2013; Accepted April 15, 2013; Published April 25, 2013
Citation: Sun RWY (2013) Strategies to Improve the Anti-Cancer Properties of Gold(III) Complexes. Mod Chem appl 1: 102. doi:10.4172/2329-6798.1000102
Copyright: © 2013 Sun RWY. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

cis-Diamminedichloroplatinum(II) (cisplatin or cis-[PtII(NH3)2(Cl)2]) with biological properties discovered serendipitously by Rosenberg in 1965 and with approval given by the Food and Drug Administration in 1978 went on to become an important clinically-used agent for the treatment of cancers. This platinum drug together with its derivatives carboplatin and oxaliplatin are highly effective towards various kinds of cancers such as testicular cancer. Nevertheless, the toxic side effects of these platinum(II) complexes, including nephrotoxicity, emetogenesis and neurotoxicity, along with the wide range of cisplatin-resistant cancer cells, make them far from ideal drugs. The tandem success and limitations of these platinum(II)-based drugs opened up a wealth of research into other classes of metal-based chemotherapeutic agents.

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