alexa Synthesis A Reagent [3-Hydroxy 4- (1-Azo-2,7-Dihydroxy) Naphthalene Sulfonic Acid] and Used it for Determination of Flourometholone in Bulk and Pharmaceutical Formulations by Spectrophotometric Method
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Synthesis A Reagent [3-Hydroxy 4- (1-Azo-2,7-Dihydroxy) Naphthalene Sulfonic Acid] and Used it for Determination of Flourometholone in Bulk and Pharmaceutical Formulations by Spectrophotometric Method

Amir Alhaj Sakur1, Malek Okdeh2* and Banana Al Fares1,2
1Department of Analytical and Food Chemistry, Faculty of Pharmacy, University of Aleppo, Syria
2Department of Analytical Chemistry, Faculty of Science, Teshreen University, Lattakia, Syria
*Corresponding Author : Malek Okdeh
Department of Analytical Chemistry, Faculty of Science
Teshreen University, Lattakia, Syria
Tel: +9634135245
E-mail: [email protected]
Received: February 29, 2016 Accepted: March 23, 2016 Published: March 28, 2016
Citation: Sakur AA, Okdeh M, Al Fares B (2016) Synthesis A Reagent [3-Hydroxy 4-(1-Azo-2,7-Dihydroxy) Naphthalene Sulfonic Acid] and Used it for Determination of Flourometholone in Bulk and Pharmaceutical Formulations by Spectrophotometric Method. Mod Chem appl 4:177. doi:10.4172/2329-6798.1000177
Copyright: © 2016 Sakur AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

A Reagent [3-hydroxyl 4- (1-azo-2,7-dihydroxyl) naphthalene Sulfonic acid] (AAN) ] has been synthesized for the determination of flourometholone (FLU) in pure form and in ophthalmic suspensions (drops) by a simple, sensitive and extraction-free spectrophotometric method. The method is based on the formation of yellow colored complex between FLU and ANN maximum at 416 nm. The stoichiometry of the complex in either form was found to be (1:1). Reaction conditions were optimized to obtain the maximum color intensity. Beer’s law was obeyed in the concentration ranges of 0.5-17.0 μg/mL. The limit of quantification (LOQ) was 0.14 μg/mL and molar absorptivity (Ɛ) values was 38555 L/ moL-1cm-1. The proposed method has been applied successfully to the analysis of FLU in pure form and in its dosage forms and no interference was observed from common excipients present in pharmaceutical formulations. Statistical comparison of the results with the reference method showed excellent agreement and indicated no significant difference in accuracy and precision.

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