alexa Synthesis and Biological Activities of 2-Carboxyphenylo
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
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Research Article

Synthesis and Biological Activities of 2-Carboxyphenyloxamoylamino Acids, their Salts with 2-ethoxy-6,9-Diaminoacridine and D-glucosamine

Khaldoon AL-Rahawi1*, Ali AL-Kaf2, Shada Yassin2, Sameh EL-Nabtity3, Kotb EL-Sayed4 and Napila AL-Shoba2
1Department of Medicinal chemistry, Faculty of Pharmacy, Sana’a University, Sana’a, 14288, Yemen
2Department of Medicinal chemistry, Faculty of Pharmacy, Sana’a University, Yemen
3Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt
4Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Egypt
*Corresponding Author : Khaldoon AL-Rahawi
Medicinal Chemistry Department
Faculty of Pharmacy, Sana’a University, Sana’a, 14288, Yemen
E-mail: [email protected]
Received January 31, 2013; Accepted March 27, 2013; Published March 29, 2013
Citation: AL-Rahawi K, AL-Kaf A, Yassin S, EL-Nabtity S, EL-Sayed K, et al. (2013) Synthesis and Biological Activities of 2-Carboxyphenyloxamoylamino Acids, their Salts with 2-ethoxy-6,9-Diaminoacridine and D-glucosamine. Adv Pharmacoepidem Drug Safety 2:129. doi:10.4172/2167-1052.1000129
Copyright: © 2013 AL-Rahawi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

As a result of this work, 17 new compounds were obtained. This group of compounds (2-carboxyphenyloxamoylamino acids) alone or with biologically active base showed diverse biological activity-Anti-inflammatory, antimicrobial and hepatoprotective activity- which can be used in medicine after further investigations.

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