Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System
- *Corresponding Author:
- Dr. Mohammad Reza Saboktakin
International Research Institute of Arian Chemie Gostar
E-mail: [email protected]
Received Date: November 08, 2012; Accepted Date: December 17, 2012; Published Date: December 19, 2012
Citation: Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA (2011) Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System. J Nanomedic Nanotechnol S4:001. doi:10.4172/2157-7439.S4-001
Copyright: © 2011 Saboktakin MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The main objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of Letrozole (LTZ) intended for breast cancer therapy. LTZ loaded thiolated chitosan (TCS) nanoparticles were prepared by emulsion-solvent evaporation method. LTZ loaded TCS nanoaprticles were characterized by infrared spectra, drug entrapment efficiency and in vitro release. The system sustained release of LTZ significantly and further investigation could exhibit its potential usefulness in breast cancer therapy. The nanoparticles of LTZ prepared from TCS - may represent a useful approach for targeting its release at its site of absorption, sustaining its release.