alexa Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System

Mohammad Reza Saboktakin1,2*, Roya M.Tabatabaie1, Abel Maharramov2 and Mohammad Ali Ramazanov2

1Nanostructured Materials synthesis Lab, International Research Institute of Arian Chemie Gostar, Tabriz, Iran

2Nanostructured Materials synthesis Lab, Baku State University, Baku, Azerbaijan

*Corresponding Author:
Dr. Mohammad Reza Saboktakin
International Research Institute of Arian Chemie Gostar
Tabriz, Iran
Tel/Fax: +00984116694803
E-mail: [email protected]

Received Date: November 08, 2012; Accepted Date: December 17, 2012; Published Date: December 19, 2012

Citation: Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA (2011) Synthesis and Characterization of Biodegradable Thiolated Chitosan Nanoparticles as Targeted Drug Delivery System. J Nanomedic Nanotechnol S4:001. doi:10.4172/2157-7439.S4-001

Copyright: © 2011 Saboktakin MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The main objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of Letrozole (LTZ) intended for breast cancer therapy. LTZ loaded thiolated chitosan (TCS) nanoparticles were prepared by emulsion-solvent evaporation method. LTZ loaded TCS nanoaprticles were characterized by infrared spectra, drug entrapment efficiency and in vitro release. The system sustained release of LTZ significantly and further investigation could exhibit its potential usefulness in breast cancer therapy. The nanoparticles of LTZ prepared from TCS - may represent a useful approach for targeting its release at its site of absorption, sustaining its release.

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